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IPR041796 is a Mre11 nuclease, N-terminal metallophosphatase domain.
<p>Mre11 (also known as SbcD in Escherichia coli) is a subunit of the MRX protein complex. This complex includes: Mre11, Rad50, and Xrs2/Nbs1, and plays a vital role in several nuclear processes including DNA double-strand break repair, telomere length maintenance, cell cycle checkpoint control, and meiotic recombination, in eukaryotes. During double-strand break repair, the MRX complex is required to hold the two ends of a broken chromosome together. In vitro studies show that Mre11 has 3'-5' exonuclease activity on dsDNA templates and endonuclease activity on dsDNA and ssDNA templates [[cite:PUB00091854], [cite:PUB00052836], [cite:PUB00026038]]. In addition to the N-terminal phosphatase domain, the eukaryotic MRE11 members of this family have a C-terminal DNA binding domain. MRE11-like proteins are found in prokaryotes and archaea was well as in eukaryotes. Mre11 belongs to the metallophosphatase (MPP) superfamily.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Double-strand break repair protein Mre11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 | ||
| – | Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 | ||
| – | Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 | ||
| – | Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |