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IPR007281 is a Mre11, DNA-binding.
<p>This entry represents the DNA binding domain of Double-strand break repair protein Mre11 and similar eukaryotic sequences.</p> <p>The MRN complex is a multi-subunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling, double-strand break (DSB) repair, DNA replication, maintenance of telomere integrity and meiosis, promoting genomic stability [[cite:PUB00009879], [cite:PUB00062772], [cite:PUB00017210], [cite:PUB00103967], [cite:PUB00061220], [cite:PUB00103968]]. Mre11 has an intrinsic DNA-binding activity that is stimulated by Rad50 on its own or in combination with Nbs1 [[cite:PUB00009878]]. This protein dimerises via phosphodiesterase domains flanked by an α/β capping domain, which creates a U-shaped particle with a broad DNA/Rad50 binding cleft [[cite:PUB00061220]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | Double-strand break repair | The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. | ||
| Molecular function | Manganese ion binding | Interacting selectively and non-covalently with manganese (Mn) ions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: double-strand break repair protein MRE11-like [Glycine max] gi|356542248|ref|XP_003539581.1| | 14 | ||
| – | PREDICTED: double-strand break repair protein MRE11-like [Glycine max] gi|356542248|ref|XP_003539581.1| | 14 | ||
| – | Double-strand break repair protein Mre11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 | ||
| – | Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 | ||
| – | Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 | ||
| – | Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |