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IPR003701 is a DNA double-strand break repair protein Mre11.
<p>Mre11 and Rad50 are two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Mre11 by itself has 3' to 5' exonuclease activity that is increased when Mre11 is in a complex with Rad50 [[cite:PUB00008183]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. | ||
| Biological process | Double-strand break repair | The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. | ||
| Molecular function | 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. | ||
| Cellular component | Mre11 complex | Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: double-strand break repair protein MRE11-like [Glycine max] gi|356542248|ref|XP_003539581.1| | 14 | ||
| – | PREDICTED: double-strand break repair protein MRE11-like [Glycine max] gi|356542248|ref|XP_003539581.1| | 14 | ||
| – | Double-strand break repair protein Mre11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 | ||
| – | Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 | ||
| – | Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 | ||
| – | Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |