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IPR040258

Source: InterPro

Description

IPR040258 is a FACT complex subunit Spt16.

<p>This entry represents a the FACT complex subunit SPT16 from diverse eukaryotes [[cite:PUB00101031], [cite:PUB00101034]]. FACT is a general chromatin factor that acts to reorganise nucleosomes [[cite:PUB00070237], [cite:PUB00070238], [cite:PUB00101032]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0035101
Cellular component FACT complex An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer.
Subterm of

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0481300.1
– FACT complex subunit SPT16; TAIR: AT4G10710.1 global transcription factor C; Swiss-Prot: sp|O82491|SPT16_ARATH FACT complex subunit SPT16; TrEMBL-Plants: tr|A0A1J7H1L5|A0A1J7H1L5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0481300
Domains
27
LotjaGi1g1v0481300.2
– FACT complex subunit SPT16; TAIR: AT4G10710.1 global transcription factor C; Swiss-Prot: sp|O82491|SPT16_ARATH FACT complex subunit SPT16; TrEMBL-Plants: tr|A0A1J7H1L5|A0A1J7H1L5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0481300
Domains
27
LotjaGi6g1v0051400.1
– FACT complex subunit SPT16; TAIR: AT4G10710.1 global transcription factor C; Swiss-Prot: sp|O82491|SPT16_ARATH FACT complex subunit SPT16; TrEMBL-Plants: tr|A0A1J7H1L5|A0A1J7H1L5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0051400
Domains
26
LotjaGi6g1v0051400.2
– FACT complex subunit SPT16; TAIR: AT4G10710.1 global transcription factor C; Swiss-Prot: sp|O82491|SPT16_ARATH FACT complex subunit SPT16; TrEMBL-Plants: tr|A0A1J7H1L5|A0A1J7H1L5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0051400
Domains
26
LotjaGi6g1v0051400.3
– FACT complex subunit SPT16; TAIR: AT4G10710.1 global transcription factor C; Swiss-Prot: sp|O82491|SPT16_ARATH FACT complex subunit SPT16; TrEMBL-Plants: tr|A0A1J7H1L5|A0A1J7H1L5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0051400
Domains
26
LotjaGi6g1v0051500.1
– FACT complex subunit SPT16; TAIR: AT4G10710.1 global transcription factor C; Swiss-Prot: sp|O82491|SPT16_ARATH FACT complex subunit SPT16; TrEMBL-Plants: tr|A0A1J7IIX4|A0A1J7IIX4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0051500
Domains
26
LotjaGi6g1v0051500.2
– FACT complex subunit SPT16; TAIR: AT4G10710.1 global transcription factor C; Swiss-Prot: sp|O82491|SPT16_ARATH FACT complex subunit SPT16; TrEMBL-Plants: tr|A0A1J7IIX4|A0A1J7IIX4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0051500
Domains
26
LotjaGi6g1v0051500.3
– FACT complex subunit SPT16; TAIR: AT4G10710.1 global transcription factor C; Swiss-Prot: sp|O82491|SPT16_ARATH FACT complex subunit SPT16; TrEMBL-Plants: tr|A0A1J7IIX4|A0A1J7IIX4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0051500
Domains
26

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 12.50