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IPR041742 is a Sec24-like, trunk domain.
<p>COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex [[cite:PUB00014931]]. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and Sec13/31 to induce coat polymerisation and membrane deformation [[cite:PUB00014933]].</p> <p>Sec23 p and Sec24p are structurally related, folding into five distinct domains: a β-barrel, a zinc-finger ([interpro:IPR006895]), an α/β trunk domain, an all-helical region ([interpro:IPR006900]), and a C-terminal gelsolin-like domain ([interpro:IPR007123]). This entry describes the Sec23/24 α/β trunk domain, which is formed from a single, approximately 250-residue segment plugged into the β-barrel between strands β1 and β19. The trunk has an α/β fold with a vWA topology, and it forms the dimer interface, primarily involving strand β14 on Sec23 and Sec24; in addition, the trunk domain of Sec23 contacts Sar1.</p> <p>This entry describes the trunk domain of Sec24, as well as some Sec24-related proteins.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. | ||
| Biological process | ER to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. | ||
| Cellular component | COPII vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Protein transport protein Sec24-like; TAIR: AT3G07100.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q9SFU0|SC24A_ARATH Protein transport protein Sec24-like At3g07100; TrEMBL-Plants: tr|I1NBN5|I1NBN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0750200 | 28 | ||
| – | Protein transport protein Sec24-like; TAIR: AT3G07100.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q9SFU0|SC24A_ARATH Protein transport protein Sec24-like At3g07100; TrEMBL-Plants: tr|I1NBN5|I1NBN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0750200 | 28 | ||
| – | Protein transport protein Sec24-like family; TAIR: AT4G32640.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q9M081|SC24B_ARATH Protein transport protein Sec24-like At4g32640; TrEMBL-Plants: tr|A0A151TQ51|A0A151TQ51_CAJCA Protein transport protein Sec24-like family; Found in the gene: LotjaGi5g1v0346900 | 30 | ||
| – | Protein transport protein Sec24-like family; TAIR: AT4G32640.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q9M081|SC24B_ARATH Protein transport protein Sec24-like At4g32640; TrEMBL-Plants: tr|A0A151TQ51|A0A151TQ51_CAJCA Protein transport protein Sec24-like family; Found in the gene: LotjaGi5g1v0346900 | 30 | ||
| – | Protein transport protein Sec24-like family; TAIR: AT3G44340.1 hypothetical protein; Swiss-Prot: sp|Q9M291|SC24C_ARATH Protein transport protein Sec24-like CEF; TrEMBL-Plants: tr|A0A151TQ51|A0A151TQ51_CAJCA Protein transport protein Sec24-like family; Found in the gene: LotjaGi5g1v0346900 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01479 | CDD | 1 | 20.00 |