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IPR036180 is a Gelsolin-like domain superfamily.
<p>Gelsolin is a cytoplasmic, calcium-regulated, actin-modulating protein that binds to the barbed ends of actin filaments, preventing monomer exchange (end-blocking or capping) [[cite:PUB00001347]]. It can promote nucleation (the assembly of monomers into filaments), as well as sever existing filaments. In addition, this protein binds with high affinity to fibronectin. Plasma gelsolin and cytoplasmic gelsolin are derived from a single gene by alternate initiation sites and differential splicing.</p> <p>Sequence comparisons indicate an evolutionary relationship between gelsolin, villin, fragmin and severin [[cite:PUB00003232]]. Six large repeating segments occur in gelsolin and villin, and 3 similar segments in severin and fragmin. While the multiple repeats have yet to be related to any known function of the actin-severing proteins, the superfamily appears to have evolved from an ancestral sequence of 120 to 130 amino acid residues [[cite:PUB00003232]].</p> <p>This gelsolin-like domain can also be found in the C-terminal of the members of Sec23/Sec24 family. They are components of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).</p> <p>The Gelsolin structure has a three layers (α/β/α) fold and a mixed β-sheet topology.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Protein transport protein Sec24-like; TAIR: AT3G07100.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q9SFU0|SC24A_ARATH Protein transport protein Sec24-like At3g07100; TrEMBL-Plants: tr|I1NBN5|I1NBN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0750200 | 28 | ||
| – | Protein transport protein Sec24-like; TAIR: AT3G07100.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q9SFU0|SC24A_ARATH Protein transport protein Sec24-like At3g07100; TrEMBL-Plants: tr|K7N2I3|K7N2I3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0750200 | 12 | ||
| – | Protein transport protein Sec24-like; TAIR: AT3G07100.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q9SFU0|SC24A_ARATH Protein transport protein Sec24-like At3g07100; TrEMBL-Plants: tr|I1NBN5|I1NBN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0750200 | 28 | ||
| – | Protein transport protein SEC23; TAIR: AT4G01810.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q0US25|SEC23_PHANO Protein transport protein SEC23; TrEMBL-Plants: tr|K7MZM9|K7MZM9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0754600 | 28 | ||
| – | Protein transport protein SEC23; TAIR: AT4G01810.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q0US25|SEC23_PHANO Protein transport protein SEC23; TrEMBL-Plants: tr|K7MZM9|K7MZM9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0754600 | 28 | ||
| – | Protein transport protein SEC23; TAIR: AT4G01810.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q0US25|SEC23_PHANO Protein transport protein SEC23; TrEMBL-Plants: tr|A0A151TXC4|A0A151TXC4_CAJCA Protein transport protein Sec23A; Found in the gene: LotjaGi1g1v0754600 | 28 | ||
| – | Protein transport protein SEC23; TAIR: AT2G21630.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|G7LEA6|G7LEA6_MEDTR Protein transporter Sec23-like protein; Found in the gene: LotjaGi3g1v0268900 | 30 | ||
| – | Protein transport protein SEC23; TAIR: AT2G21630.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|G7LEA6|G7LEA6_MEDTR Protein transporter Sec23-like protein; Found in the gene: LotjaGi3g1v0268900 | 30 | ||
| – | Villin; TAIR: AT4G30160.1 villin 4; Swiss-Prot: sp|O65570|VILI4_ARATH Villin-4; TrEMBL-Plants: tr|K7LWU7|K7LWU7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0303900 | 27 | ||
| – | Villin; TAIR: AT4G30160.1 villin 4; Swiss-Prot: sp|O65570|VILI4_ARATH Villin-4; TrEMBL-Plants: tr|K7LWU7|K7LWU7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0303900 | 27 | ||
| – | Protein transport protein SEC23; TAIR: AT1G05520.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|A0A1J7GI99|A0A1J7GI99_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0368900 | 30 | ||
| – | Protein transport protein SEC23; TAIR: AT1G05520.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|A0A1J7GI99|A0A1J7GI99_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0368900 | 28 | ||
| – | Protein transport protein Sec24-like family; TAIR: AT4G32640.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q9M081|SC24B_ARATH Protein transport protein Sec24-like At4g32640; TrEMBL-Plants: tr|A0A151TQ51|A0A151TQ51_CAJCA Protein transport protein Sec24-like family; Found in the gene: LotjaGi5g1v0346900 | 30 | ||
| – | Protein transport protein Sec24-like family; TAIR: AT4G32640.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q9M081|SC24B_ARATH Protein transport protein Sec24-like At4g32640; TrEMBL-Plants: tr|A0A151TQ51|A0A151TQ51_CAJCA Protein transport protein Sec24-like family; Found in the gene: LotjaGi5g1v0346900 | 30 | ||
| – | Protein transport protein Sec24-like family; TAIR: AT3G44340.1 hypothetical protein; Swiss-Prot: sp|Q9M291|SC24C_ARATH Protein transport protein Sec24-like CEF; TrEMBL-Plants: tr|A0A151TQ51|A0A151TQ51_CAJCA Protein transport protein Sec24-like family; Found in the gene: LotjaGi5g1v0346900 | 24 | ||
| – | Protein transport protein SEC23; TAIR: AT5G43670.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|G8A123|G8A123_MEDTR Protein transporter Sec23-like protein; Found in the gene: LotjaGi6g1v0038800 | 30 | ||
| – | Protein transport protein SEC23; TAIR: AT1G05520.1 Sec23/Sec24 protein transport family protein; Swiss-Prot: sp|Q4PE39|SEC23_USTMA Protein transport protein SEC23; TrEMBL-Plants: tr|G7JBC0|G7JBC0_MEDTR Protein transporter Sec23-like protein; Found in the gene: LotjaGi6g1v0103600 | 31 | ||
| – | Villin; TAIR: AT4G30160.1 villin 4; Swiss-Prot: sp|O65570|VILI4_ARATH Villin-4; TrEMBL-Plants: tr|A0A0L9UAV1|A0A0L9UAV1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0240100 | 26 | ||
| – | Villin; TAIR: AT4G30160.1 villin 4; Swiss-Prot: sp|O65570|VILI4_ARATH Villin-4; TrEMBL-Plants: tr|A0A0L9UAV1|A0A0L9UAV1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0240100 | 25 | ||
| – | Villin; TAIR: AT4G30160.1 villin 4; Swiss-Prot: sp|O65570|VILI4_ARATH Villin-4; TrEMBL-Plants: tr|A0A0L9UAV1|A0A0L9UAV1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0240100 | 25 | ||
| – | Villin; TAIR: AT4G30160.1 villin 4; Swiss-Prot: sp|O65570|VILI4_ARATH Villin-4; TrEMBL-Plants: tr|A0A0L9UAV1|A0A0L9UAV1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0240100 | 26 | ||
| – | Villin; TAIR: AT4G30160.1 villin 4; Swiss-Prot: sp|O65570|VILI4_ARATH Villin-4; TrEMBL-Plants: tr|A0A0L9UAV1|A0A0L9UAV1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0240100 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 4.55 |