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8-oxoguanine DNA glycosylase, N-terminal domain
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Damaged DNA binding | Interacting selectively and non-covalently with damaged DNA. | ||
| Biological process | Nucleotide-excision repair | A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). | ||
| Molecular function | Oxidized purine nucleobase lesion DNA N-glycosylase activity | Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: N-glycosylase/DNA lyase OGG1-like isoform X1 [Cicer arietinum] gi|502135915|ref|XP_004502497.1| | 13 | ||
| – | N-glycosylase/DNA lyase [Medicago truncatula] gi|357463557|ref|XP_003602060.1| | 14 | ||
| – | N-glycosylase/DNA lyase; TAIR: AT1G21710.1 8-oxoguanine-DNA glycosylase 1; Swiss-Prot: sp|Q9FNY7|OGG1_ARATH N-glycosylase/DNA lyase OGG1; TrEMBL-Plants: tr|A0A0S3RDM0|A0A0S3RDM0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0263300 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |