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GO:0036402

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description Proteasome-activating ATPase activity
Full defintion Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.
Subterm of

Relationships

The relationship of GO:0036402 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCrb
PMID
The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release.Köhler A, Cascio P, Leggett DS, Woo KM, Goldberg AL, Finley D
Mol Cell. 2001 Jun; 7 (6): 1143–52.PMID: 11430818

Substrates enter the proteasome core particle (CP) through a channel that opens upon association with the regulatory particle (RP). Using yeast mutants, we show that channel opening is mediated by the ATPase domain of Rpt2, one of six ATPases in the RP. To test whether degradation products exit through this channel, we analyzed their size distribution. Their median length from an open-channel CP mutant was 40% greater than that from the wild-type. Thus, channel opening may enhance the yield of peptides long enough to function in antigen presentation. These experiments demonstrate that gating of the RP channel controls both substrate entry and product release, and is specifically regulated by an ATPase in the base of the RP.

Associated Lotus transcripts 8

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
LotjaGi4g1v0351800.1
– 26S protease regulatory subunit; TAIR: AT5G58290.1 regulatory particle triple-A ATPase 3; Swiss-Prot: sp|Q9SEI4|PRS6B_ARATH 26S protease regulatory subunit 6B homolog; TrEMBL-Plants: tr|A0A151U9T4|A0A151U9T4_CAJCA 26S protease regulatory subunit 6B isogeny; Found in the gene: LotjaGi4g1v0351800
GO terms
1
LotjaGi4g1v0351800.2
– 26S protease regulatory subunit; TAIR: AT5G58290.1 regulatory particle triple-A ATPase 3; Swiss-Prot: sp|P54778|PRS6B_SOLTU 26S protease regulatory subunit 6B homolog; TrEMBL-Plants: tr|V7BPD9|V7BPD9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0351800
GO terms
1
LotjaGi4g1v0351800.3
– 26S protease regulatory subunit; TAIR: AT5G58290.1 regulatory particle triple-A ATPase 3; Swiss-Prot: sp|P54778|PRS6B_SOLTU 26S protease regulatory subunit 6B homolog; TrEMBL-Plants: tr|A0A0R0EW30|A0A0R0EW30_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0351800
GO terms
1
LotjaGi4g1v0351800.4
– 26S protease regulatory subunit; TAIR: AT5G58290.1 regulatory particle triple-A ATPase 3; Swiss-Prot: sp|Q9SEI4|PRS6B_ARATH 26S protease regulatory subunit 6B homolog; TrEMBL-Plants: tr|A0A151U9T4|A0A151U9T4_CAJCA 26S protease regulatory subunit 6B isogeny; Found in the gene: LotjaGi4g1v0351800
GO terms
1
LotjaGi6g1v0045000.1
– 26S protease regulatory subunit; TAIR: AT5G58290.1 regulatory particle triple-A ATPase 3; Swiss-Prot: sp|Q9SEI4|PRS6B_ARATH 26S protease regulatory subunit 6B homolog; TrEMBL-Plants: tr|A0A0R4J4L8|A0A0R4J4L8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0045000
GO terms
1
LotjaGi6g1v0045000.3
– 26S protease regulatory subunit; TAIR: AT5G58290.1 regulatory particle triple-A ATPase 3; Swiss-Prot: sp|Q9SEI4|PRS6B_ARATH 26S protease regulatory subunit 6B homolog; TrEMBL-Plants: tr|A0A0R4J4L8|A0A0R4J4L8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0045000
GO terms
1
LotjaGi6g1v0045000.4
– 26S protease regulatory subunit; TAIR: AT5G58290.1 regulatory particle triple-A ATPase 3; Swiss-Prot: sp|Q9SEI4|PRS6B_ARATH 26S protease regulatory subunit 6B homolog; TrEMBL-Plants: tr|A0A0R4J4L8|A0A0R4J4L8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0045000
GO terms
1
LotjaGi6g1v0045000.5
– 26S protease regulatory subunit; TAIR: AT5G58290.1 regulatory particle triple-A ATPase 3; Swiss-Prot: sp|Q9SEI4|PRS6B_ARATH 26S protease regulatory subunit 6B homolog; TrEMBL-Plants: tr|A0A151U9T4|A0A151U9T4_CAJCA 26S protease regulatory subunit 6B isogeny; Found in the gene: LotjaGi6g1v0045000
GO terms
1

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0036402
Molecular function Proteasome-activating ATPase activity 1 12.50