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IPR000150 is a Cof family.
<p>The Haloacid Dehydrogenase (HAD) superfamily includes phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, which are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification [[cite:PUB00003337]]. Proteins in this entry are mostly uncharacterised, though they form a distinct subgroup within the HAD superfamily. Members are found almost exclusively in bacteria and many species contain several paralogs, for example Escherichia coli contains a total of six proteins from this entry. Sequence similarities suggest that these enzymes are phosphatases which work on phosphorylated sugars.</p> <p>This entry represents a family belonging to the HAD superfamily. It is named after E. coli Cof and is notable for the large number of paralogues in many species. Cof is a phosphatase that catalyzes the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate) to HMP-P (4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate) [[cite:PUB00053972]].</p> <p>E. coli YbiV ([swissprot:P75792]) also belongs to this group and has been experimentally characterised [[cite:PUB00028115]]. This enzyme catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. It has a wide substrate specificity, catalyzing the hydrolysis of ribose-5-phosphate and glucose-6-phosphate most efficiently, but it is not known if these are the real substrates in vivo. The protein appears to be a monomer that contains two domains, an α-β hydrolase domain that forms a Rossman fold, and an α-β domain. The active site is found in a negatively charged cavity found at the interface between the two domains.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Haloacid dehalogenase-like hydrolase family protein isoform 2 [Theobroma cacao] gi|508782554|gb|EOY29810.1| | 24 | ||
| – | Endoribonuclease YbeY; TAIR: AT2G25870.1 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|Q5XD45|Y533_STRP6 Putative phosphatase M6_Spy0533; TrEMBL-Plants: tr|I1M9Z5|I1M9Z5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0222600 | 26 | ||
| – | Endoribonuclease YbeY; TAIR: AT2G25870.1 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|Q5XD45|Y533_STRP6 Putative phosphatase M6_Spy0533; TrEMBL-Plants: tr|A0A0B2SRP5|A0A0B2SRP5_GLYSO Putative rRNA maturation factor; Found in the gene: LotjaGi1g1v0222600 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07516 | CDD | 1 | 33.33 |