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IPR002036 is a Endoribonuclease YbeY.
<p>YbeY is a single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. It acts together with the RNase R to eliminate defective 70S ribosomes, but not properly matured 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. It is involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'-and 3'-ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs [[cite:PUB00064741], [cite:PUB00064742], [cite:PUB00064743], [cite:PUB00038326], [cite:PUB00096939]].</p> <p>The crystal structure of the protein from the hyperthermophilic bacteria Aquifex aeolicus has been determined. The overall fold consists of one central α-helix surrounded by a four-stranded β-sheet and four other α-helices. Structure-based homology analysis reveals a good resemblance to the metal-dependent proteinases such as collagenases and gelatinases. However, experimental tests for collagenase and gelatinase-type function show no detectable activity under standard assay conditions [[cite:PUB00027806]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. | ||
| Biological process | RRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Haloacid dehalogenase-like hydrolase family protein isoform 2 [Theobroma cacao] gi|508782554|gb|EOY29810.1| | 24 | ||
| – | Endoribonuclease YbeY; TAIR: AT2G25870.1 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|Q5XD45|Y533_STRP6 Putative phosphatase M6_Spy0533; TrEMBL-Plants: tr|I1M9Z5|I1M9Z5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0222600 | 26 | ||
| – | Endoribonuclease YbeY; TAIR: AT2G25870.1 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|Q5XD45|Y533_STRP6 Putative phosphatase M6_Spy0533; TrEMBL-Plants: tr|A0A0B2SRP5|A0A0B2SRP5_GLYSO Putative rRNA maturation factor; Found in the gene: LotjaGi1g1v0222600 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07516 | CDD | 1 | 33.33 |