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IPR023091

Source: InterPro

Description

IPR023091 is a Metalloprotease catalytic domain superfamily, predicted.

<p>This superfamily represents a domain found in a number of predicted metalloproteases. The crystal structure of the protein from the hyperthermophilic bacteria Aquifex aeolicus has been determined. The overall fold consists of one central α-helix surrounded by a four-stranded β-sheet and four other α-helices. Structure-based homology analysis reveals a good resemblance to metalloproteases such as collagenases and gelatinases. However, experimental tests for collagenase and gelatinase-type function show no detectable activity under standard assay conditions [[cite:PUB00027806]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004222
Molecular function Metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj0g3v0295639.1
– Haloacid dehalogenase-like hydrolase family protein isoform 2 [Theobroma cacao] gi|508782554|gb|EOY29810.1|
Domains
24
LotjaGi1g1v0222600.1
– Endoribonuclease YbeY; TAIR: AT2G25870.1 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|Q5XD45|Y533_STRP6 Putative phosphatase M6_Spy0533; TrEMBL-Plants: tr|I1M9Z5|I1M9Z5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0222600
Domains
26
LotjaGi1g1v0222600.2
– Endoribonuclease YbeY; TAIR: AT2G25870.1 haloacid dehalogenase-like hydrolase family protein; Swiss-Prot: sp|Q5XD45|Y533_STRP6 Putative phosphatase M6_Spy0533; TrEMBL-Plants: tr|A0A0B2SRP5|A0A0B2SRP5_GLYSO Putative rRNA maturation factor; Found in the gene: LotjaGi1g1v0222600
Domains
26

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd07516 CDD 1 33.33