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IPR000705 is a Galactokinase.
<p>Galactokinase catalyses the first reaction in the galactose metabolism pathway, the ATP-dependent phosphorylation of galactose, yielding galactose-1-phosphate [[cite:PUB00003653], [cite:PUB00004765]]. Deficiency in this enzyme results in the disease galactosemia, which is responsible for the formation of cataracts in newborn babies, and is possibly responsible for presenile cataracts in adults [[cite:PUB00004765]]. In yeast, the GAL3 gene product is required for the GAL4-mediated induction of other enzymes involved in galactose metabolism. The induction of GAL1 production then reinforces this process, increasing the expression of other galactose-inducible genes. GAL3 has been shown to be similar to the GAL1 protein [[cite:PUB00003653]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Galactokinase activity | Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+). | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Galactose metabolic process | The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. | ||
| Biological process | Carbohydrate phosphorylation | The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: galactokinase-like [Glycine max] gi|356565073|ref|XP_003550769.1| | 24 | ||
| – | PREDICTED: galactokinase-like [Cicer arietinum] gi|502150796|ref|XP_004508128.1| | 24 | ||
| – | Galactokinase [Medicago truncatula] gi|357520677|ref|XP_003630627.1| | 18 | ||
| – | Galactokinase; TAIR: AT3G06580.1 Mevalonate/galactokinase family protein; Swiss-Prot: sp|Q9SEE5|GALK1_ARATH Galactokinase; TrEMBL-Plants: tr|I1MRT3|I1MRT3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0332900 | 26 | ||
| – | Galactokinase; TAIR: AT3G10700.1 galacturonic acid kinase; Swiss-Prot: sp|Q8VYG2|GALAK_ARATH Galacturonokinase; TrEMBL-Plants: tr|G7LJJ0|G7LJJ0_MEDTR Galactokinase; Found in the gene: LotjaGi4g1v0440500 | 19 | ||
| – | Galactokinase; TAIR: AT3G06580.1 Mevalonate/galactokinase family protein; Swiss-Prot: sp|Q9SEE5|GALK1_ARATH Galactokinase; TrEMBL-Plants: tr|I1MRT3|I1MRT3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0260600 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00131 | TIGRFAM | 1 | 16.67 |