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IPR019741

Source: InterPro

Description

IPR019741 is a Galactokinase, conserved site.

<p>This entry represents a conserved signature pattern located in the N-terminal domain of galactokinases.</p> <p>Galactokinase catalyses the first reaction in the galactose metabolism pathway, the ATP-dependent phosphorylation of galactose, yielding galactose-1-phosphate [[cite:PUB00003653], [cite:PUB00004765]]. Deficiency in this enzyme results in the disease galactosemia, which is responsible for the formation of cataracts in newborn babies, and is possibly responsible for presenile cataracts in adults [[cite:PUB00004765]]. In yeast, the GAL3 gene product is required for the GAL4-mediated induction of other enzymes involved in galactose metabolism. The induction of GAL1 production then reinforces this process, increasing the expression of other galactose-inducible genes. GAL3 has been shown to be similar to the GAL1 protein [[cite:PUB00003653]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj0g3v0357339.1
– PREDICTED: galactokinase-like [Glycine max] gi|356565073|ref|XP_003550769.1|
Domains
24
Lj4g3v2263880.1
– PREDICTED: galactokinase-like [Cicer arietinum] gi|502150796|ref|XP_004508128.1|
Domains
24
LotjaGi4g1v0332900.1
– Galactokinase; TAIR: AT3G06580.1 Mevalonate/galactokinase family protein; Swiss-Prot: sp|Q9SEE5|GALK1_ARATH Galactokinase; TrEMBL-Plants: tr|I1MRT3|I1MRT3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0332900
Domains
26
LotjaGi6g1v0260600.1
– Galactokinase; TAIR: AT3G06580.1 Mevalonate/galactokinase family protein; Swiss-Prot: sp|Q9SEE5|GALK1_ARATH Galactokinase; TrEMBL-Plants: tr|I1MRT3|I1MRT3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0260600
Domains
26

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00131 TIGRFAM 1 25.00