Description

IPR001015 is a Ferrochelatase.

<p>Synonym(s): Protohaem ferro-lyase, Iron chelatase, etc. <p>Ferrochelatase is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ubiquitous in nature and widely distributed in bacteria and eukaryotes. Recently, some archaeal members have been identified. The oligomeric state of these enzymes varies depending on the presence of a dimerization motif at the C terminus [[cite:PUB00012956], [cite:PUB00079463], [cite:PUB00079464], [cite:PUB00079466], [cite:PUB00079467], [cite:PUB00079465], [cite:PUB00006693], [cite:PUB00022076], [cite:PUB00021315], [cite:PUB00026989], [cite:PUB00002620], [cite:PUB00004754]]. In eukaryotic cells, it binds to the mitochondrial inner membrane with its active site on the matrix side of the membrane.</p> <p>The X-ray structure of<i>Bacillus subtilis</i>and human ferrochelatase have been solved [[cite:PUB00006691], [cite:PUB00006693]]. The human enzyme exists as a homodimer. Each subunit contains one [2Fe-2S] cluster. The monomer is folded into two similar domains, each with a four-stranded parallel β-sheet flanked by an α-helix in a β-α-β motif that is reminiscent of the fold found in the periplasmic binding proteins. The topological similarity between the domains suggests that they have arisen from a gene duplication event. However, significant differences exist between the two domains, including an N-terminal section (residues 80-130) that forms part of the active site pocket, and a C-terminal extension (residues 390-423) that is involved in coordination of the [2Fe-2S] cluster and in stabilisation of the homodimer.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: