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IPR001180 is a Citron homology (CNH) domain.
<p>Based on sequence similarities a domain of homology has been identified in the following proteins [[cite:PUB00006609], [cite:PUB00068730]]:</p> <ul> <li>Citron and Citron kinase. These two proteins interact with the GTP-bound forms of the small GTPases Rho and Rac but not with Cdc42.</li> <li>Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCKalpha). This serine/threonine kinase interacts with the GTP-bound form of the small GTPase Cdc42 and to a lesser extent with that of Rac.</li> <li>NCK Interacting Kinase (NIK), a serine/threonine protein kinase.</li> <li>ROM-1 and ROM-2, from yeast. These proteins are GDP/GTP exchange proteins (GEPs) for the small GTP binding protein Rho1.</li> </ul> <p>This domain, called the citron homology domain (CNH), is often found after cysteine rich and pleckstrin homology (PH) domains at the C-terminal end of a group of eukaryotic proteins. It is thought to act as a regulatory domain and could be involved in macromolecular interactions [[cite:PUB00006609], [cite:PUB00006610], [cite:PUB00101189], [cite:PUB00101188]]. Its structure has been solved in Rho guanyl nucleotide exchange factor (Rom2) from Neosartorya fumigata (Aspergillus fumigatus, [swissprot:Q4WUI2]), where it shows a canonical β-propeller fold containing seven blades connected by small loops and arranged in a circular fashion [[cite:PUB00101190]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: vam6/Vps39-like protein-like isoform X2 [Cicer arietinum] gi|502153212|ref|XP_004509258.1| | 12 | ||
| – | PREDICTED: vam6/Vps39-like protein-like [Glycine max] gi|356496767|ref|XP_003517237.1| | 18 | ||
| – | PREDICTED: transforming growth factor-beta receptor-associated protein 1 homolog isoform X1 [Cicer arietinum] gi|502155930|ref|XP_004510242.1| | 11 | ||
| – | Vam6/Vps39-like protein; TAIR: AT4G36630.2 Vacuolar sorting protein 39; Swiss-Prot: sp|Q8R5L3|VPS39_MOUSE Vam6/Vps39-like protein; TrEMBL-Plants: tr|G7LES7|G7LES7_MEDTR Vam6/Vps39-like protein; Found in the gene: LotjaGi1g1v0416300 | 14 | ||
| – | Vam6/Vps39-like protein; TAIR: AT4G36630.1 Vacuolar sorting protein 39; Swiss-Prot: sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein; TrEMBL-Plants: tr|A0A0R0LJG6|A0A0R0LJG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0390200 | 16 | ||
| – | Vam6/Vps39-like protein; TAIR: AT4G36630.1 Vacuolar sorting protein 39; Swiss-Prot: sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein; TrEMBL-Plants: tr|A0A0R0LJG6|A0A0R0LJG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0390200 | 16 | ||
| – | Transforming growth factor-beta receptor-associated protein 1; TAIR: AT1G22860.1 Vacuolar sorting protein 39; Swiss-Prot: sp|A4IG72|TGFA1_DANRE Transforming growth factor-beta receptor-associated protein 1 homolog; TrEMBL-Plants: tr|A0A072TMN8|A0A072TMN8_MEDTR Vacuolar sorting protein 39 domain protein; Found in the gene: LotjaGi3g1v0087800 | 12 | ||
| – | Vam6/Vps39-like protein; TAIR: AT4G36630.1 Vacuolar sorting protein 39; Swiss-Prot: sp|Q8R5L3|VPS39_MOUSE Vam6/Vps39-like protein; TrEMBL-Plants: tr|G7LES7|G7LES7_MEDTR Vam6/Vps39-like protein; Found in the gene: LotjaGi4g1v0117000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |