Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR032914

Source: InterPro

Description

IPR032914 is a Vam6/VPS39/TRAP1 family.

<p>This entry includes fungal Vam6/Vps3 and animal Vps39/TRAP1. Vps39 is also known as Vam6 or TRAP1-Like-Protein (TLP) [[cite:PUB00077765]]. Vam6/Vps39 acts as a component of the HOPS complex that functions during the docking stage of vacuole fusion. It is required for late endosomal-lysosomal fusion events and the delivery of endocytic cargo to lysosomes [[cite:PUB00068730], [cite:PUB00077161]]. In addition to its regulatory role in homotypic vacuolar fusion and vacuole protein sorting within the HOPS complex, Vam6 also controls the function of the central regulator of eukaryotic cell growth TORC1 by activating the Gtr1 subunit of the EGO complex [[cite:PUB00077766], [cite:PUB00077160]].</p> <p>TRAP1 plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway [[cite:PUB00086665]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016192
Biological process Vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
Subterm of

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
Lj0g3v0185019.1
– PREDICTED: vam6/Vps39-like protein-like isoform X2 [Cicer arietinum] gi|502153212|ref|XP_004509258.1|
Domains
7
Lj0g3v0259479.1
– PREDICTED: vam6/Vps39-like protein-like isoform X2 [Cicer arietinum] gi|502153212|ref|XP_004509258.1|
Domains
12
Lj2g3v1757300.1
– PREDICTED: vam6/Vps39-like protein-like [Glycine max] gi|356496767|ref|XP_003517237.1|
Domains
18
LotjaGi1g1v0416300.1
– Vam6/Vps39-like protein; TAIR: AT4G36630.2 Vacuolar sorting protein 39; Swiss-Prot: sp|Q8R5L3|VPS39_MOUSE Vam6/Vps39-like protein; TrEMBL-Plants: tr|G7LES7|G7LES7_MEDTR Vam6/Vps39-like protein; Found in the gene: LotjaGi1g1v0416300
Domains
14
LotjaGi2g1v0390200.1
– Vam6/Vps39-like protein; TAIR: AT4G36630.1 Vacuolar sorting protein 39; Swiss-Prot: sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein; TrEMBL-Plants: tr|A0A0R0LJG6|A0A0R0LJG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0390200
Domains
16
LotjaGi2g1v0390200.2
– Vam6/Vps39-like protein; TAIR: AT4G36630.1 Vacuolar sorting protein 39; Swiss-Prot: sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein; TrEMBL-Plants: tr|A0A0R0LJG6|A0A0R0LJG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0390200
Domains
16
LotjaGi3g1v0087800.1
– Transforming growth factor-beta receptor-associated protein 1; TAIR: AT1G22860.1 Vacuolar sorting protein 39; Swiss-Prot: sp|A4IG72|TGFA1_DANRE Transforming growth factor-beta receptor-associated protein 1 homolog; TrEMBL-Plants: tr|A0A072TMN8|A0A072TMN8_MEDTR Vacuolar sorting protein 39 domain protein; Found in the gene: LotjaGi3g1v0087800
Domains
12
LotjaGi4g1v0117000.1
– Vam6/Vps39-like protein; TAIR: AT4G36630.1 Vacuolar sorting protein 39; Swiss-Prot: sp|Q8R5L3|VPS39_MOUSE Vam6/Vps39-like protein; TrEMBL-Plants: tr|G7LES7|G7LES7_MEDTR Vam6/Vps39-like protein; Found in the gene: LotjaGi4g1v0117000
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 12.50