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IPR019452 is a Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1.
<p>This entry represents a domain found in the vacuolar sorting protein Vps39 and transforming growth factor beta receptor-associated protein Trap1. Vps39, a component of the C-Vps complex, is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole [[cite:PUB00044536], [cite:PUB00044537]]. In Saccharomyces cerevisiae (Baker's yeast), Vps39 has been shown to stimulate nucleotide exchange [[cite:PUB00044538]]. Trap1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling [[cite:PUB00045376], [cite:PUB00045377]]. The precise function of this domain has not been characterised.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: vam6/Vps39-like protein-like isoform X2 [Cicer arietinum] gi|502153212|ref|XP_004509258.1| | 12 | ||
| – | PREDICTED: vam6/Vps39-like protein-like [Glycine max] gi|356496767|ref|XP_003517237.1| | 18 | ||
| – | PREDICTED: transforming growth factor-beta receptor-associated protein 1 homolog isoform X1 [Cicer arietinum] gi|502155930|ref|XP_004510242.1| | 11 | ||
| – | PREDICTED: transforming growth factor-beta receptor-associated protein 1 homolog isoform X1 [Cicer arietinum] gi|502155930|ref|XP_004510242.1| | 8 | ||
| – | Vam6/Vps39-like protein; TAIR: AT4G36630.2 Vacuolar sorting protein 39; Swiss-Prot: sp|Q8R5L3|VPS39_MOUSE Vam6/Vps39-like protein; TrEMBL-Plants: tr|G7LES7|G7LES7_MEDTR Vam6/Vps39-like protein; Found in the gene: LotjaGi1g1v0416300 | 14 | ||
| – | Vam6/Vps39-like protein; TAIR: AT4G36630.1 Vacuolar sorting protein 39; Swiss-Prot: sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein; TrEMBL-Plants: tr|A0A0R0LJG6|A0A0R0LJG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0390200 | 16 | ||
| – | Vam6/Vps39-like protein; TAIR: AT4G36630.1 Vacuolar sorting protein 39; Swiss-Prot: sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein; TrEMBL-Plants: tr|A0A0R0LJG6|A0A0R0LJG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0390200 | 16 | ||
| – | Transforming growth factor-beta receptor-associated protein 1; TAIR: AT1G22860.1 Vacuolar sorting protein 39; Swiss-Prot: sp|A4IG72|TGFA1_DANRE Transforming growth factor-beta receptor-associated protein 1 homolog; TrEMBL-Plants: tr|A0A072TMN8|A0A072TMN8_MEDTR Vacuolar sorting protein 39 domain protein; Found in the gene: LotjaGi3g1v0087800 | 12 | ||
| – | Vam6/Vps39-like protein; TAIR: AT4G36630.1 Vacuolar sorting protein 39; Swiss-Prot: sp|Q8R5L3|VPS39_MOUSE Vam6/Vps39-like protein; TrEMBL-Plants: tr|G7LES7|G7LES7_MEDTR Vam6/Vps39-like protein; Found in the gene: LotjaGi4g1v0117000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |