Description

IPR001711 is a Phospholipase C, phosphatidylinositol-specific, Y domain.

<p>Phosphatidylinositol-specific phospholipase C ([ec:3.1.4.11]), an eukaryotic intracellular enzyme, plays an important role in signal transduction processes [[cite:PUB00000624]] (see [interpro:IPR001192]). It catalyzes the hydrolysis of 1-phosphatidyl-D-myo-inositol-3,4,5-triphosphate into the second messenger molecules diacylglycerol and inositol-1,4,5-triphosphate. This catalytic process is tightly regulated by reversible phosphorylation and binding of regulatory proteins [[cite:PUB00000014], [cite:PUB00002715], [cite:PUB00005394]].</p> <p>In mammals, there are at least 6 different isoforms of PI-PLC, they differ in their domain structure, their regulation, and their tissue distribution. Lower eukaryotes also possess multiple isoforms of PI-PLC.</p> <p>All eukaryotic PI-PLCs contain two regions of homology, sometimes referred to as 'X-box' (see [interpro:IPR000909]) and 'Y-box'. The order of these two regions is always the same (NH2-X-Y-COOH), but the spacing is variable. In most isoforms, the distance between these two regions is only 50-100 residues but in the gamma isoforms one PH domain, two SH2 domains, and one SH3 domain are inserted between the two PLC-specific domains. The two conserved regions have been shown to be important for the catalytic activity. At the C-terminal of the Y-box, there is a C2 domain (see [interpro:IPR000008]) possibly involved in Ca-dependent membrane attachment.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: