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IPR017946

Source: InterPro

Description

IPR017946 is a PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily.

<p>This superfamily represents a structural domain consisting of a TIM β/α-barrel. These domains are found in several phospholipase C (PLC) like phosphodiesterases, including:</p> <ul><li>Mammalian phospholipase C isozyme D1 [[cite:PUB00030187]].</li> <li>Bacterial phosphatidylinositol-specific phospholipase C [[cite:PUB00023203]].</li> <li>Glycerophosphodiester phosphodiesterases, such as GlpQ from Escherichia coli and UgpQ from Agrobacterium tumefaciens [[cite:PUB00038838]].</li></ul> <p>Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyse phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate. PLC enzymes often play central roles in various signalling cascades [[cite:PUB00043827]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006629
Biological process Lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
Subterm of
GO:0008081
Molecular function Phosphoric diester hydrolase activity Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
Subterm of

Associated Lotus transcripts 67

Transcript Name Description Predicted domains Domain count
Lj0g3v0063279.1
– PREDICTED: PI-PLC X domain-containing protein At5g67130-like isoform X2 [Cicer arietinum] gi|502152866|ref|XP_004509132.1|
Domains
19
Lj0g3v0105159.1
– PREDICTED: probable glycerophosphoryl diester phosphodiesterase 3-like [Glycine max] gi|356546095|ref|XP_003541467.1|
Domains
8
Lj0g3v0105169.1
–
Domains
8
Lj0g3v0105189.1
– PREDICTED: probable glycerophosphoryl diester phosphodiesterase 3-like [Glycine max] gi|356546095|ref|XP_003541467.1|
Domains
14
Lj0g3v0130579.1
– PREDICTED: phosphoinositide phospholipase C 6-like [Cicer arietinum] gi|502097439|ref|XP_004490993.1|
Domains
29
Lj0g3v0189439.1
– PREDICTED: phosphoinositide phospholipase C 6-like [Cicer arietinum] gi|502129978|ref|XP_004500489.1|
Domains
17
Lj0g3v0189439.3
– Phosphoinositide phospholipase C [Medicago truncatula] gi|357461225|ref|XP_003600894.1|
Domains
11
Lj0g3v0276839.1
– PREDICTED: probable glycerophosphoryl diester phosphodiesterase 2-like [Glycine max] gi|356569693|ref|XP_003553031.1|
Domains
16
Lj0g3v0276839.2
– PREDICTED: probable glycerophosphoryl diester phosphodiesterase 2-like [Glycine max] gi|356569693|ref|XP_003553031.1|
Domains
16
Lj1g3v3041520.1
– PREDICTED: PI-PLC X domain-containing protein At5g67130-like [Glycine max] gi|356567107|ref|XP_003551764.1|
Domains
15
Lj1g3v3041530.1
– PREDICTED: PI-PLC X domain-containing protein At5g67130-like [Glycine max] gi|356567109|ref|XP_003551765.1|
Domains
4
Lj1g3v3343840.1
– PLC-like phosphodiesterases superfamily protein [Theobroma cacao] gi|508705833|gb|EOX97729.1|
Domains
10
Lj1g3v3343840.2
– PREDICTED: 1-phosphatidylinositol phosphodiesterase-like [Glycine max] gi|356516666|ref|XP_003527014.1|
Domains
3
Lj1g3v3892190.1
– PREDICTED: glycerophosphodiester phosphodiesterase GDE1-like [Cicer arietinum] gi|502106611|ref|XP_004492997.1|
Domains
8
Lj2g3v1880850.1
– PREDICTED: PI-PLC X domain-containing protein At5g67130-like isoform X1 [Cicer arietinum] gi|502160829|ref|XP_004511918.1|
Domains
14
Lj2g3v1890930.1
– PREDICTED: PI-PLC X domain-containing protein At5g67130-like [Glycine max] gi|356540674|ref|XP_003538811.1|
Domains
19
Lj2g3v2256390.1
– PREDICTED: phosphoinositide phospholipase C 4-like [Cicer arietinum] gi|502096021|ref|XP_004490600.1|
Domains
29
Lj2g3v2256400.1
– PREDICTED: phosphoinositide phospholipase C 2-like [Cicer arietinum] gi|502096024|ref|XP_004490601.1|
Domains
26
Lj2g3v2747660.1
– PREDICTED: phosphoinositide phospholipase C 6-like [Glycine max] gi|356553781|ref|XP_003545231.1|
Domains
19
Lj2g3v2747660.2
– PREDICTED: phosphoinositide phospholipase C 6-like isoform X1 [Cicer arietinum] gi|502097427|ref|XP_004490990.1|
Domains
19
Lj2g3v2748690.1
– PREDICTED: phosphoinositide phospholipase C 2-like [Cicer arietinum] gi|502097443|ref|XP_004490994.1|
Domains
21
Lj2g3v3224570.1
– PREDICTED: probable glycerophosphoryl diester phosphodiesterase 1-like [Glycine max] gi|356524319|ref|XP_003530777.1|
Domains
14
Lj3g3v1956740.1
– PLC-like phosphodiesterases superfamily protein isoform 1 [Theobroma cacao] gi|508725081|gb|EOY16978.1|
Domains
11
Lj3g3v1956740.2
– PLC-like phosphodiesterases superfamily protein isoform 2 [Theobroma cacao] gi|508725082|gb|EOY16979.1|
Domains
7
Lj3g3v1956740.4
– PLC-like phosphodiesterases superfamily protein isoform 1 [Theobroma cacao] gi|508725081|gb|EOY16978.1|
Domains
14
Lj3g3v3500040.1
– Phosphoinositide-specific phospholipase C [Populus tomentosa] gi|407232756|gb|AFT82720.1|
Domains
10
Lj3g3v3500050.1
– PREDICTED: 1-phosphatidylinositol phosphodiesterase-like [Glycine max] gi|356516666|ref|XP_003527014.1|
Domains
11
Lj4g3v0620030.1
– PREDICTED: PI-PLC X domain-containing protein At5g67130-like [Glycine max] gi|356502503|ref|XP_003520058.1|
Domains
15
Lj4g3v0620060.2
– PREDICTED: PI-PLC X domain-containing protein At5g67130-like [Glycine max] gi|356502505|ref|XP_003520059.1|
Domains
15
Lj6g3v0521600.1
– Phospholipase C [Pisum sativum] gi|21955869|emb|CAA75546.2|
Domains
18
Lj6g3v0521600.2
– PREDICTED: phosphoinositide phospholipase C 2-like isoform X1 [Cicer arietinum] gi|502129981|ref|XP_004500490.1|
Domains
29
Lj6g3v0521600.3
– PREDICTED: phosphoinositide phospholipase C 2-like isoform X2 [Cicer arietinum] gi|502129984|ref|XP_004500491.1|
Domains
29
Lj6g3v0521670.1
– PREDICTED: phosphoinositide phospholipase C 6-like [Glycine max] gi|356539975|ref|XP_003538468.1|
Domains
27
Lj6g3v0814490.1
– PREDICTED: probable glycerophosphoryl diester phosphodiesterase 3-like [Glycine max] gi|356501592|ref|XP_003519608.1|
Domains
13
Lj6g3v1078490.1
– PREDICTED: probable glycerophosphoryl diester phosphodiesterase 3-like [Glycine max] gi|356546095|ref|XP_003541467.1|
Domains
8
LotjaGi1g1v0021800.1
– Glycerophosphodiester phosphodiesterase; TAIR: AT5G55480.1 SHV3-like 1; Swiss-Prot: sp|Q9FJ62|GPDL4_ARATH Glycerophosphodiester phosphodiesterase GDPDL4; TrEMBL-Plants: tr|I1JJF7|I1JJF7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0021800
Domains
18
LotjaGi1g1v0077600.1
– Phosphoinositide phospholipase C; TAIR: AT3G08510.1 phospholipase C 2; Swiss-Prot: sp|Q39033|PLCD2_ARATH Phosphoinositide phospholipase C 2; TrEMBL-Plants: tr|Q43443|Q43443_SOYBN Phosphoinositide phospholipase C; Found in the gene: LotjaGi1g1v0077600
Domains
29
LotjaGi1g1v0077700.1
– Phosphoinositide phospholipase C; TAIR: AT2G40116.1 Phosphoinositide-specific phospholipase C family protein; Swiss-Prot: sp|Q8GV43|PLCD6_ARATH Phosphoinositide phospholipase C 6; TrEMBL-Plants: tr|G7KH09|G7KH09_MEDTR Phosphoinositide phospholipase C; Found in the gene: LotjaGi1g1v0077700
Domains
29
LotjaGi1g1v0077700.2
– Phosphoinositide phospholipase C; TAIR: AT2G40116.1 Phosphoinositide-specific phospholipase C family protein; Swiss-Prot: sp|Q8GV43|PLCD6_ARATH Phosphoinositide phospholipase C 6; TrEMBL-Plants: tr|G7KH09|G7KH09_MEDTR Phosphoinositide phospholipase C; Found in the gene: LotjaGi1g1v0077700
Domains
29
LotjaGi1g1v0077700.3
– Phosphoinositide phospholipase C; TAIR: AT2G40116.1 Phosphoinositide-specific phospholipase C family protein; Swiss-Prot: sp|Q8GV43|PLCD6_ARATH Phosphoinositide phospholipase C 6; TrEMBL-Plants: tr|G7KH09|G7KH09_MEDTR Phosphoinositide phospholipase C; Found in the gene: LotjaGi1g1v0077700
Domains
26
LotjaGi1g1v0077800.1
– Phosphoinositide phospholipase C; TAIR: AT2G40116.1 Phosphoinositide-specific phospholipase C family protein; Swiss-Prot: sp|Q8GV43|PLCD6_ARATH Phosphoinositide phospholipase C 6; TrEMBL-Plants: tr|A0A151R1A5|A0A151R1A5_CAJCA Phosphoinositide phospholipase C; Found in the gene: LotjaGi1g1v0077800
Domains
28
LotjaGi1g1v0120100.1
– Phosphoinositide phospholipase C; TAIR: AT3G08510.1 phospholipase C 2; Swiss-Prot: sp|Q39033|PLCD2_ARATH Phosphoinositide phospholipase C 2; TrEMBL-Plants: tr|G7JZH5|G7JZH5_MEDTR Phosphoinositide phospholipase C; Found in the gene: LotjaGi1g1v0120100
Domains
27
LotjaGi1g1v0120200.1
– Phosphoinositide phospholipase C; TAIR: AT5G58700.1 phosphatidylinositol-speciwc phospholipase C4; Swiss-Prot: sp|Q944C1|PLCD4_ARATH Phosphoinositide phospholipase C 4; TrEMBL-Plants: tr|G7KE98|G7KE98_MEDTR Phosphoinositide phospholipase C; Found in the gene: LotjaGi1g1v0120200
Domains
30
LotjaGi1g1v0515400.1
– PI-PLC X domain-containing protein; TAIR: AT1G13680.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|K7MUZ9|K7MUZ9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0515400
Domains
14
LotjaGi1g1v0515400.2
– PI-PLC X domain-containing protein; TAIR: AT1G13680.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|K7MUZ9|K7MUZ9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0515400
Domains
4
LotjaGi1g1v0559900.1
– 1-phosphatidylinositol phosphodiesterase-like protein; TAIR: AT4G38690.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|P34024|PLC_LISMO 1-phosphatidylinositol phosphodiesterase; TrEMBL-Plants: tr|I3T950|I3T950_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0559900
Domains
11
LotjaGi1g1v0629200.1
– Glycerophosphodiester phosphodiesterase, putative; TAIR: AT3G02040.1 senescence-related gene 3; Swiss-Prot: sp|Q9SGA2|GDPD1_ARATH Glycerophosphodiester phosphodiesterase GDPD1, chloroplastic; TrEMBL-Plants: tr|A0A0L9U6F2|A0A0L9U6F2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0629200
Domains
8
LotjaGi2g1v0267800.1
– PI-PLC X domain-containing protein family; TAIR: AT1G13680.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|A0A151RVR7|A0A151RVR7_CAJCA PI-PLC X domain-containing protein family; Found in the gene: LotjaGi2g1v0267800
Domains
7
LotjaGi2g1v0402400.1
– PI-PLC X domain-containing protein family; TAIR: AT4G36945.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|A0A151TIF2|A0A151TIF2_CAJCA PI-PLC X domain-containing protein family; Found in the gene: LotjaGi2g1v0402400
Domains
13
LotjaGi2g1v0403100.1
– PI-PLC X domain-containing protein family; TAIR: AT5G67130.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|I1LHC8|I1LHC8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0403100
Domains
17
LotjaGi2g1v0403100.2
– PI-PLC X domain-containing protein family; TAIR: AT5G67130.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|I1LHC8|I1LHC8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0403100
Domains
17
LotjaGi2g1v0403100.3
– PI-PLC X domain-containing protein; TAIR: AT5G67130.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|V7CF23|V7CF23_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0403100
Domains
14
LotjaGi3g1v0334600.1
– Glycerophosphodiester phosphodiesterase family protein; TAIR: AT1G71340.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|F4I8H8|GDPD4_ARATH Glycerophosphodiester phosphodiesterase GDPD4; TrEMBL-Plants: tr|A0A072USJ9|A0A072USJ9_MEDTR Glycerophosphodiester phosphodiesterase family protein; Found in the gene: LotjaGi3g1v0334600
Domains
12
LotjaGi4g1v0075700.1
– PI-PLC X domain-containing protein; TAIR: AT1G49740.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|Q75PK4|Q75PK4_LOTJA Putative uncharacterized protein LjNUF; Found in the gene: LotjaGi4g1v0075700
Domains
10
LotjaGi4g1v0075700.2
– PI-PLC X domain-containing protein; TAIR: AT1G49740.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|Q75PK4|Q75PK4_LOTJA Putative uncharacterized protein LjNUF; Found in the gene: LotjaGi4g1v0075700
Domains
15
LotjaGi4g1v0075700.3
– PI-PLC X domain-containing protein; TAIR: AT1G49740.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|Q75PK4|Q75PK4_LOTJA Putative uncharacterized protein LjNUF; Found in the gene: LotjaGi4g1v0075700
Domains
10
LotjaGi4g1v0075800.1
– PI-PLC X domain-containing protein; TAIR: AT1G49740.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|I3SWA4|I3SWA4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0075800
Domains
14
LotjaGi4g1v0103000.1
– PI-PLC X domain-containing protein family; TAIR: AT5G67130.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|A0A072UQZ4|A0A072UQZ4_MEDTR Pi-PLC X domain plant-like protein; Found in the gene: LotjaGi4g1v0103000
Domains
18
LotjaGi4g1v0103000.2
– PI-PLC X domain-containing protein family; TAIR: AT5G67130.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q93XX5|Y5713_ARATH PI-PLC X domain-containing protein At5g67130; TrEMBL-Plants: tr|A0A072UQZ4|A0A072UQZ4_MEDTR Pi-PLC X domain plant-like protein; Found in the gene: LotjaGi4g1v0103000
Domains
16
LotjaGi4g1v0255300.1
– Glycerophosphodiester phosphodiesterase; TAIR: AT1G74210.1 PLC-like phosphodiesterases superfamily protein; Swiss-Prot: sp|Q9C907|GDPD5_ARATH Glycerophosphodiester phosphodiesterase GDPD5; TrEMBL-Plants: tr|A0A072URQ0|A0A072URQ0_MEDTR Glycerophosphoryl diester phosphodiesterase family protein; Found in the gene: LotjaGi4g1v0255300
Domains
15
LotjaGi4g1v0285800.1
– Glycerophosphoryl diester phosphodiesterase family protein; TAIR: AT5G58170.1 SHV3-like 5; Swiss-Prot: sp|Q9LVN0|GPDL7_ARATH Glycerophosphodiester phosphodiesterase GDPDL7; TrEMBL-Plants: tr|A0A1J7I0E2|A0A1J7I0E2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0285800
Domains
17
LotjaGi6g1v0074900_LC.1
– Phosphoinositide phospholipase C; TAIR: AT5G58690.1 phosphatidylinositol-speciwc phospholipase C5; Swiss-Prot: sp|Q944C2|PLCD5_ARATH Phosphoinositide phospholipase C 5; TrEMBL-Plants: tr|G7JBA2|G7JBA2_MEDTR Phosphoinositide phospholipase C; Found in the gene: LotjaGi6g1v0074900_LC
Domains
13
LotjaGi6g1v0075400.1
– Phosphoinositide phospholipase C; TAIR: AT2G40116.1 Phosphoinositide-specific phospholipase C family protein; Swiss-Prot: sp|Q8GV43|PLCD6_ARATH Phosphoinositide phospholipase C 6; TrEMBL-Plants: tr|K7LRR0|K7LRR0_SOYBN Phosphoinositide phospholipase C; Found in the gene: LotjaGi6g1v0075400
Domains
27
LotjaGi6g1v0075500.1
– Phosphoinositide phospholipase C; TAIR: AT3G08510.1 phospholipase C 2; Swiss-Prot: sp|Q39033|PLCD2_ARATH Phosphoinositide phospholipase C 2; TrEMBL-Plants: tr|A0A0S3S0S5|A0A0S3S0S5_PHAAN Phosphoinositide phospholipase C; Found in the gene: LotjaGi6g1v0075500
Domains
30
LotjaGi6g1v0075500.2
– Phosphoinositide phospholipase C; TAIR: AT3G08510.1 phospholipase C 2; Swiss-Prot: sp|Q39033|PLCD2_ARATH Phosphoinositide phospholipase C 2; TrEMBL-Plants: tr|A0A0S3S0S5|A0A0S3S0S5_PHAAN Phosphoinositide phospholipase C; Found in the gene: LotjaGi6g1v0075500
Domains
30
LotjaGi6g1v0151000.1
– Glycerophosphodiester phosphodiesterase; TAIR: AT4G26690.1 PLC-like phosphodiesterase family protein; Swiss-Prot: sp|Q9SZ11|GPDL3_ARATH Glycerophosphodiester phosphodiesterase GDPDL3; TrEMBL-Plants: tr|K7MQP5|K7MQP5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0151000
Domains
16
LotjaGi6g1v0205400.1
– Glycerophosphodiester phosphodiesterase; TAIR: AT5G58170.1 SHV3-like 5; Swiss-Prot: sp|Q9LVN0|GPDL7_ARATH Glycerophosphodiester phosphodiesterase GDPDL7; TrEMBL-Plants: tr|A0A1J7H9U8|A0A1J7H9U8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0205400
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 1.49