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IPR002034

Source: InterPro

Description

IPR002034 is a Alpha-isopropylmalate/homocitrate synthase, conserved site.

<p>A number of enzymes have been shown to be functionally as well as evolutionary related [[cite:PUB00002139]]. The nifV and leuA genes encode homocitrate synthase and alpha-isopropylmalate synthase, respectively The N-terminal parts of NifV and LeuA from bacteria are highly similar to each other [[cite:PUB00006373]]. Homocitrate synthase ([ec:2.3.3.14]) (gene nifV) is involved in the biosynthesis of the iron-molybdenum cofactor of nitrogenase and catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate into homocitrate. Alpha-isopropylmalate synthase ([ec:2.3.3.13]) catalyses the first step in the biosynthesis of leucine, the condensation ofacetyl-CoA and alpha-ketoisovalerate to form 2-isopropylmalate synthase.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0019752
Biological process Carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
Subterm of
GO:0046912
Molecular function Transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.
Subterm of

Associated Lotus transcripts 12

Transcript Name Description Predicted domains Domain count
Lj1g3v3690020.1
– Homocitrate synthase [Lotus japonicus] gi|268607430|dbj|BAI49592.1|
Domains
16
Lj1g3v3690020.2
– Homocitrate synthase [Lotus japonicus] gi|268607430|dbj|BAI49592.1|
Domains
14
Lj1g3v3690020.3
– Homocitrate synthase [Lotus japonicus] gi|268607430|dbj|BAI49592.1|
Domains
12
Lj1g3v3690180.1
– Homocitrate synthase [Lotus japonicus] gi|268607430|dbj|BAI49592.1|
Domains
19
Lj1g3v3690180.2
– Homocitrate synthase [Lotus japonicus] gi|268607430|dbj|BAI49592.1|
Domains
13
Lj1g3v3690250.1
– Homocitrate synthase [Lotus japonicus] gi|268607430|dbj|BAI49592.1|
Domains
10
Lj5g3v2298240.1
– PREDICTED: 2-isopropylmalate synthase 2, chloroplastic-like [Cicer arietinum] gi|502121886|ref|XP_004497478.1|
Domains
18
LotjaGi1g1v0613100.1
– 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q39891|LEU1_SOYBN Probable 2-isopropylmalate synthase; TrEMBL-Plants: tr|D0VY45|D0VY45_LOTJA Homocitrate synthase; Found in the gene: LotjaGi1g1v0613100
Domains
19
LotjaGi1g1v0613300.1
– 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q39891|LEU1_SOYBN Probable 2-isopropylmalate synthase; TrEMBL-Plants: tr|D0VY45|D0VY45_LOTJA Homocitrate synthase; Found in the gene: LotjaGi1g1v0613300
Domains
22
LotjaGi1g1v0613400.1
– 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q39891|LEU1_SOYBN Probable 2-isopropylmalate synthase; TrEMBL-Plants: tr|D0VY45|D0VY45_LOTJA Homocitrate synthase; Found in the gene: LotjaGi1g1v0613400
Domains
26
LotjaGi1g1v0613400.2
– 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q39891|LEU1_SOYBN Probable 2-isopropylmalate synthase; TrEMBL-Plants: tr|D0VY45|D0VY45_LOTJA Homocitrate synthase; Found in the gene: LotjaGi1g1v0613400
Domains
24
LotjaGi5g1v0362600.1
– 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q9C550|LEU12_ARATH 2-isopropylmalate synthase 2, chloroplastic; TrEMBL-Plants: tr|I1NJA5|I1NJA5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0362600
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd07940 CDD 1 8.33