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IPR036230 is a 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain superfamily.
<p>This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway [[cite:PUB00020847]]. This domain, is an internally duplicated structure with a novel fold [[cite:PUB00020847]]. It comprises two similar units that are arranged such that the two helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel β-sheets. The overall domain is thus constructed as a β-α-β three-layer sandwich [[cite:PUB00020847]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q39891|LEU1_SOYBN Probable 2-isopropylmalate synthase; TrEMBL-Plants: tr|D0VY45|D0VY45_LOTJA Homocitrate synthase; Found in the gene: LotjaGi1g1v0613100 | 19 | ||
– | 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q39891|LEU1_SOYBN Probable 2-isopropylmalate synthase; TrEMBL-Plants: tr|D0VY45|D0VY45_LOTJA Homocitrate synthase; Found in the gene: LotjaGi1g1v0613300 | 22 | ||
– | 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q39891|LEU1_SOYBN Probable 2-isopropylmalate synthase; TrEMBL-Plants: tr|D0VY45|D0VY45_LOTJA Homocitrate synthase; Found in the gene: LotjaGi1g1v0613400 | 26 | ||
– | 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q39891|LEU1_SOYBN Probable 2-isopropylmalate synthase; TrEMBL-Plants: tr|D0VY45|D0VY45_LOTJA Homocitrate synthase; Found in the gene: LotjaGi1g1v0613400 | 24 | ||
– | 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q9C550|LEU12_ARATH 2-isopropylmalate synthase 2, chloroplastic; TrEMBL-Plants: tr|I1NJA5|I1NJA5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0362600 | 21 | ||
– | 2-isopropylmalate synthase; TAIR: AT1G74040.1 2-isopropylmalate synthase 1; Swiss-Prot: sp|Q9C550|LEU12_ARATH 2-isopropylmalate synthase 2, chloroplastic; TrEMBL-Plants: tr|I1NJA5|I1NJA5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0362600 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
SSF51569 | SUPERFAMILY | 1 | 16.67 |