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IPR002208 is a SecY/SEC61-alpha family.
<p>This family consists of the protein translocase subunit SecY and protein transport protein Sec61 subunit alpha (Sec61a).</p> <p>Sec61a is part of the Sec61 complex, which plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins.</p> <p>Secretion across the inner membrane in some Gram-negative bacteria occurs via the preprotein translocase pathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase component [[cite:PUB00007064]]. From there, the mature proteins are either targeted to the outer membrane, or remain as periplasmic proteins. The translocase protein subunits are encoded on the bacterial chromosome.</p> <p>The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF) [[cite:PUB00007064]]. The chaperone protein SecB [[cite:PUB00007065]] is a highly acidic homotetrameric protein that exists as a "dimer of dimers" in the bacterial cytoplasm. SecB maintains preproteins in an unfolded state after translation, and targets these to the peripheral membrane protein ATPase SecA for secretion [[cite:PUB00007066]]. The structure of the Escherichia coli SecYEG assembly revealed a sandwich of two membranes interacting through the extensive cytoplasmic domains [[cite:PUB00007187]]. Each membrane is composed of dimers of SecYEG. The monomeric complex contains 15 transmembrane helices.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | ||
| Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: preprotein translocase subunit SCY2, chloroplastic-like isoform X1 [Cicer arietinum] gi|502109502|ref|XP_004493661.1| | 13 | ||
| – | PREDICTED: protein transport protein Sec61 subunit alpha-like [Glycine max] gi|356543211|ref|XP_003540056.1| | 16 | ||
| – | PREDICTED: preprotein translocase subunit secY, chloroplastic-like [Glycine max] gi|356517020|ref|XP_003527188.1| | 15 | ||
| – | PREDICTED: preprotein translocase subunit secY, chloroplastic-like [Glycine max] gi|356517020|ref|XP_003527188.1| | 18 | ||
| – | Protein translocase secy subunit, putative; TAIR: AT2G31530.1 SecY protein transport family protein; Swiss-Prot: sp|F4IQV7|SCY2_ARATH Preprotein translocase subunit SCY2, chloroplastic; TrEMBL-Plants: tr|I1JNT8|I1JNT8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0728300 | 13 | ||
| – | Protein translocase secy subunit, putative; TAIR: AT2G31530.1 SecY protein transport family protein; Swiss-Prot: sp|F4IQV7|SCY2_ARATH Preprotein translocase subunit SCY2, chloroplastic; TrEMBL-Plants: tr|A0A0R0EYD4|A0A0R0EYD4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0728300 | 11 | ||
| – | Protein translocase secy subunit, putative; TAIR: AT2G31530.1 SecY protein transport family protein; Swiss-Prot: sp|F4IQV7|SCY2_ARATH Preprotein translocase subunit SCY2, chloroplastic; TrEMBL-Plants: tr|A0A0R0EYD4|A0A0R0EYD4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0728300 | 11 | ||
| – | Protein translocase secy subunit, putative; TAIR: AT2G31530.1 SecY protein transport family protein; Swiss-Prot: sp|F4IQV7|SCY2_ARATH Preprotein translocase subunit SCY2, chloroplastic; TrEMBL-Plants: tr|V7CYE8|V7CYE8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0728300 | 13 | ||
| – | Protein transport protein Sec61 subunit alpha; TAIR: AT2G34250.1 SecY protein transport family protein; Swiss-Prot: sp|Q54XK2|SC61A_DICDI Protein transport protein Sec61 subunit alpha; TrEMBL-Plants: tr|A0A1J7HEZ2|A0A1J7HEZ2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0113300 | 17 | ||
| – | Protein transport protein Sec61 subunit alpha; TAIR: AT2G34250.1 SecY protein transport family protein; Swiss-Prot: sp|Q54XK2|SC61A_DICDI Protein transport protein Sec61 subunit alpha; TrEMBL-Plants: tr|A0A1J7HEZ2|A0A1J7HEZ2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0113300 | 17 | ||
| – | Protein translocase secy subunit, putative; TAIR: AT2G18710.1 SECY homolog 1; Swiss-Prot: sp|Q9XQU4|SECY_PEA Preprotein translocase subunit SECY, chloroplastic; TrEMBL-Plants: tr|I1KDG6|I1KDG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0198400 | 18 | ||
| – | Protein translocase secy subunit, putative; TAIR: AT2G18710.1 SECY homolog 1; Swiss-Prot: sp|Q9XQU4|SECY_PEA Preprotein translocase subunit SECY, chloroplastic; TrEMBL-Plants: tr|I1KDG6|I1KDG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0198400 | 16 | ||
| – | Protein translocase secy subunit, putative; TAIR: AT2G18710.1 SECY homolog 1; Swiss-Prot: sp|Q9XQU4|SECY_PEA Preprotein translocase subunit SECY, chloroplastic; TrEMBL-Plants: tr|I1KDG6|I1KDG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0198400 | 16 | ||
| – | Protein translocase secy subunit, putative; TAIR: AT2G18710.1 SECY homolog 1; Swiss-Prot: sp|Q9XQU4|SECY_PEA Preprotein translocase subunit SECY, chloroplastic; TrEMBL-Plants: tr|I1KDG6|I1KDG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0198400 | 16 | ||
| – | Protein translocase secy subunit, putative; TAIR: AT2G18710.1 SECY homolog 1; Swiss-Prot: sp|Q9XQU4|SECY_PEA Preprotein translocase subunit SECY, chloroplastic; TrEMBL-Plants: tr|I1KDG6|I1KDG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0198400 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 6.67 |