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IPR002343

Source: InterPro

Description

IPR002343 is a Paraneoplastic encephalomyelitis antigen.

<p>Many eukaryotic proteins that are either known or thought to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids [[cite:PUB00001891], [cite:PUB00005341]]. This region has been found in, for example, heterogeneous nuclear ribonucleoproteins, small nuclear ribonucleoproteins, pre-RNA and mRNA associated proteins, Drosophila sex determination and elav proteins, human paraneoplastic encephalomyelitis antigen HuD, and many others. The structure of an RNA-binding domain of Drosophila Sex-lethal (Sxl) protein has been determined using multi-dimensional hetero-nuclear NMR [[cite:PUB00000396]]. Sxl contains two RNP consensus-type RNA-binding domains (RBDs) - the determined structure represents the second of these (RBD-2) [[cite:PUB00000396]]. The calculated intermediate-resolution family of structures exhibits the β-α-β/β-α-β tertiary fold found in other RBD-containing proteins [[cite:PUB00000396]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003723
Molecular function RNA binding Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
Subterm of
GO:1990904
Cellular component Ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules.
Subterm of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj1g3v4764260.1
– PREDICTED: CUGBP Elav-like family member 4-like isoform X2 [Cicer arietinum] gi|502112389|ref|XP_004494315.1|
Domains
14
Lj4g3v0620300.2
– Poly(A)-binding protein [Medicago truncatula] gi|357475273|ref|XP_003607922.1|
Domains
20
Lj4g3v0620300.3
– PREDICTED: polyadenylate-binding protein 2-like [Glycine max] gi|356499763|ref|XP_003518706.1|
Domains
21
LotjaGi1g1v0744100.1
– RNA binding protein, putative; TAIR: AT4G03110.1 RNA-binding protein-defense related 1; Swiss-Prot: sp|Q8LFS6|BRN1L_ARATH RNA-binding protein BRN1; TrEMBL-Plants: tr|A0A072UF20|A0A072UF20_MEDTR RNA-binding (RRM/RBD/RNP motif) family protein; Found in the gene: LotjaGi1g1v0744100
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 25.00