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IPR002452 is a Alpha tubulin.
<p>Microtubules are polymers of tubulin, a dimer of two 55kDa subunits, designated alpha and beta [[cite:PUB00000039], [cite:PUB00000978]]. Within the microtubule lattice, α-β heterodimers associate in a head-to-tail fashion, giving rise to microtubule polarity. Fluorescent labelling studies have suggested that tubulin is oriented in microtubules with beta-tubulin toward the plus end [[cite:PUB00006112]]. For maximal rate and extent of polymerisation into microtubules, tubulin requires GTP. Two molecules of GTP are bound at different sites, termed N and E. At the E (Exchangeable) site, GTP is hydrolysed during incorporation into the microtubule. Close to the E site is an invariant region rich in glycine residues, which is found in both chains and is thought to control access of the nucleotide to its binding site [[cite:PUB00002443]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. | ||
| Molecular function | GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. | ||
| Cellular component | Microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. | ||
| Biological process | Microtubule-based process | Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Tubulin alpha-7 chain [Medicago truncatula] gi|357466771|ref|XP_003603670.1| | 24 | ||
| – | PREDICTED: tubulin alpha-1 chain [Vitis vinifera] gi|225435758|ref|XP_002285721.1| | 23 | ||
| – | Alpha-tubulin, partial [Populus alba] gi|403329628|gb|AFR42124.1| | 13 | ||
| – | RecName: Full=Tubulin alpha-3 chain; AltName: Full=Alpha-3-tubulingi|2511535|gb|AAC05719.1| alpha-tubulin 3 [Eleusine indica] gi|6094431|sp|O22349.1|TBA3_ELEIN | 25 | ||
| – | PREDICTED: tubulin alpha chain-like [Cicer arietinum] gi|502120143|ref|XP_004496862.1| | 23 | ||
| – | Tubulin alpha chain; TAIR: AT1G04820.1 tubulin alpha-4 chain; Swiss-Prot: sp|P46259|TBA1_PEA Tubulin alpha-1 chain; TrEMBL-Plants: tr|A0A0L9UGJ9|A0A0L9UGJ9_PHAAN Tubulin alpha chain; Found in the gene: LotjaGi1g1v0412500 | 26 | ||
| – | Tubulin alpha chain; TAIR: AT4G14960.1 Tubulin/FtsZ family protein; Swiss-Prot: sp|Q6VAG0|TBA2_GOSHI Tubulin alpha-2 chain; TrEMBL-Plants: tr|W9QUC8|W9QUC8_9ROSA Tubulin alpha chain; Found in the gene: LotjaGi1g1v0412500 | 22 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|O22349|TBA3_ELEIN Tubulin alpha-3 chain; TrEMBL-Plants: tr|I1ML11|I1ML11_SOYBN Tubulin alpha chain; Found in the gene: LotjaGi1g1v0643600 | 25 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|O22349|TBA3_ELEIN Tubulin alpha-3 chain; TrEMBL-Plants: tr|I1ML11|I1ML11_SOYBN Tubulin alpha chain; Found in the gene: LotjaGi1g1v0643600 | 25 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|Q02245|TBA5_MAIZE Tubulin alpha-5 chain; TrEMBL-Plants: tr|A0A151TKV5|A0A151TKV5_CAJCA Tubulin alpha chain; Found in the gene: LotjaGi2g1v0077400_LC | 14 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|Q02245|TBA5_MAIZE Tubulin alpha-5 chain; TrEMBL-Plants: tr|A0A151TKV5|A0A151TKV5_CAJCA Tubulin alpha chain; Found in the gene: LotjaGi2g1v0077400_LC | 14 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|P28752|TBA1_ORYSJ Tubulin alpha-1 chain; TrEMBL-Plants: tr|A0A0L9VLH4|A0A0L9VLH4_PHAAN Tubulin alpha chain; Found in the gene: LotjaGi2g1v0107000 | 26 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|Q56WH1|TBA3_ARATH Tubulin alpha-3 chain; TrEMBL-Plants: tr|A0A0L9VLH4|A0A0L9VLH4_PHAAN Tubulin alpha chain; Found in the gene: LotjaGi2g1v0107000 | 24 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|Q56WH1|TBA3_ARATH Tubulin alpha-3 chain; TrEMBL-Plants: tr|A0A0L9VLH4|A0A0L9VLH4_PHAAN Tubulin alpha chain; Found in the gene: LotjaGi2g1v0107000 | 24 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|Q56WH1|TBA3_ARATH Tubulin alpha-3 chain; TrEMBL-Plants: tr|A0A151TKV5|A0A151TKV5_CAJCA Tubulin alpha chain; Found in the gene: LotjaGi4g1v0376700 | 27 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|Q56WH1|TBA3_ARATH Tubulin alpha-3 chain; TrEMBL-Plants: tr|A0A151TKV5|A0A151TKV5_CAJCA Tubulin alpha chain; Found in the gene: LotjaGi4g1v0376700 | 24 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|Q56WH1|TBA3_ARATH Tubulin alpha-3 chain; TrEMBL-Plants: tr|A0A151TKV5|A0A151TKV5_CAJCA Tubulin alpha chain; Found in the gene: LotjaGi4g1v0376700 | 27 | ||
| – | Tubulin alpha chain; TAIR: AT5G19770.1 tubulin alpha-3; Swiss-Prot: sp|Q56WH1|TBA3_ARATH Tubulin alpha-3 chain; TrEMBL-Plants: tr|A0A151TKV5|A0A151TKV5_CAJCA Tubulin alpha chain; Found in the gene: LotjaGi4g1v0376700 | 27 | ||
| – | Tubulin alpha chain; TAIR: AT1G04820.1 tubulin alpha-4 chain; Swiss-Prot: sp|Q6VAF9|TBA4_GOSHI Tubulin alpha-4 chain; TrEMBL-Plants: tr|A0A1J7FT38|A0A1J7FT38_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0319800 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02186 | CDD | 1 | 5.26 |