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IPR002501 is a Pseudouridine synthase II, N-terminal.
<p>This entry represents an N-terminal domain found in pseudouridine synthase TruB, as well as Cbf5p that modifies rRNA [[cite:PUB00001931]].</p> <p>TruB is found in all domains of life and it is responsible for the pseudouridine residue present in the T loops of virtually all tRNAs. TruB recognises the preformed 3D structure of the T loop primarily through shape complementarity. It accesses its substrate uridyl residue by flipping out the nucleotide and disrupts the tertiary structure of tRNA [[cite:PUB00026665]].</p> <p>Pseudouridine synthases catalyse the isomerisation of uridine to pseudouridine (Psi) in a variety of RNA molecules, and may function as RNA chaperones. Pseudouridine is the most abundant modified nucleotide found in all cellular RNAs. There are four distinct families of pseudouridine synthases that share no global sequence similarity, but which do share the same fold of their catalytic domain(s) and uracil-binding site and are descended from a common molecular ancestor. The catalytic domain consists of two subdomains, each of which has an α+β structure that has some similarity to the ferredoxin-like fold (note: some pseudouridine synthases contain additional domains). The active site is the most conserved structural region of the superfamily and is located between the two homologous domains. These families are [[cite:PUB00045922], [cite:PUB00092579]]:</p> <ul><li>Pseudouridine synthase I, TruA.</li> <li>Pseudouridine synthase II, TruB, which contains and additional C-terminal PUA domain.</li> <li>Pseudouridine synthase RsuA. RluB, RluE and RluF are also part of this family.</li> <li>Pseudouridine synthase RluA. TruC, RluC and RluD belong to this family.</li> <li>Pseudouridine synthase TruD, which has a natural circular permutation in the catalytic domain, as well as an insertion of a family-specific α+β subdomain.</li></ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Pseudouridine synthase family protein [Arabidopsis thaliana] gi|186522847|ref|NP_196950.2| | 8 | ||
| – | Pseudouridine synthase family protein [Arabidopsis thaliana] gi|186522847|ref|NP_196950.2| | 8 | ||
| – | PREDICTED: H/ACA ribonucleoprotein complex subunit 4-like [Glycine max] gi|356525850|ref|XP_003531534.1| | 24 | ||
| – | PREDICTED: H/ACA ribonucleoprotein complex subunit 4-like [Glycine max] gi|356525850|ref|XP_003531534.1| | 24 | ||
| – | TRNA pseudouridine synthase B; TAIR: AT5G14460.1 Pseudouridine synthase family protein; Swiss-Prot: sp|A0JUU8|TRUB_ARTS2 tRNA pseudouridine synthase B; TrEMBL-Plants: tr|D7M6J7|D7M6J7_ARALL Putative uncharacterized protein; Found in the gene: LotjaGi2g1v0239300 | 13 | ||
| – | TRNA pseudouridine synthase B; TAIR: AT5G14460.1 Pseudouridine synthase family protein; Swiss-Prot: sp|Q9RB36|TRUB_FLAJ1 tRNA pseudouridine synthase B; TrEMBL-Plants: tr|A0A072U4X6|A0A072U4X6_MEDTR tRNA pseudouridine synthase B; Found in the gene: LotjaGi2g1v0239300 | 18 | ||
| – | TRNA pseudouridine synthase B; TAIR: AT3G57150.1 homologue of NAP57; Swiss-Prot: sp|Q9LD90|CBF5_ARATH H/ACA ribonucleoprotein complex subunit 4; TrEMBL-Plants: tr|V7BUX8|V7BUX8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0350500 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |