Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR002687 is a Nop domain.
<p>This entry represents the Nop domain.</p> <p>The Nop domain is present in various pre-RNA processing ribonucleoproteins (RNP):</p> <ul> <li>Eukaryotic Prp31, part of a tri-snRNP complex. It is involved in pre-mRNA splicing.</li> <li>Eukaryotic Nucleolar proteins 56 and 58 (Nop56 and Nop58), components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.</li> <li>Archaeal Nop5, an homologue of Nop56/Nop58.</li></ul> <p>The Nop domain is a RNP binding module, exhibiting RNA and protein binding surfaces. It is oval-shaped and exclusively α-helical [[cite:PUB00027813], [cite:PUB00062919]].</p> <p>U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) is involved in pre-mRNA splicing as component of the spliceosome [[cite:PUB00044450], [cite:PUB00090272]]. This protein is required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome [[cite:PUB00044450]]. It is associated with a progressive pigmentary retinopathy characterised by night vision blindness and loss of midperipheral visual field [[cite:PUB00044451], [cite:PUB00062921]].</p> <p>Nucleolar protein 56 and 58 (NOP56/58) are required for 60S ribosomal subunit synthesis [[cite:PUB00003706]]. They are core components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles [[cite:PUB00097816], [cite:PUB00090687], [cite:PUB00097817], [cite:PUB00097817]]. In humans, NOP56 is associated with a type of slowly progressive neurodegenerative disorder characterised by late-onset ataxia followed by variable involvement of the motor neuron system [[cite:PUB00103405], [cite:PUB00103406]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: U4/U6 small nuclear ribonucleoprotein Prp31-like isoform X2 [Cicer arietinum] gi|502100538|ref|XP_004491744.1| | 11 | ||
| – | PREDICTED: nucleolar protein 56-like, partial [Glycine max] gi|356529505|ref|XP_003533331.1| | 8 | ||
| – | PREDICTED: nucleolar protein 56-like isoform 1 [Glycine max] gi|356513997|ref|XP_003525694.1| | 9 | ||
| – | PREDICTED: nucleolar protein 56-like [Glycine max] gi|356563188|ref|XP_003549846.1| | 8 | ||
| – | PREDICTED: nucleolar protein 56-like [Glycine max] gi|356563188|ref|XP_003549846.1| | 9 | ||
| – | SAR DNA-binding protein-like protein [Lotus japonicus] gi|33945887|emb|CAE45597.1| | 12 | ||
| – | U4/U6 small nuclear ribonucleoprotein Prp31; TAIR: AT1G60170.1 pre-mRNA processing ribonucleoprotein binding region-containing protein; Swiss-Prot: sp|Q8RXN6|PRP31_ARATH U4/U6 small nuclear ribonucleoprotein Prp31 homolog; TrEMBL-Plants: tr|A0A0S3TBB0|A0A0S3TBB0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0618800 | 17 | ||
| – | U4/U6 small nuclear ribonucleoprotein Prp31; TAIR: AT1G60170.1 pre-mRNA processing ribonucleoprotein binding region-containing protein; Swiss-Prot: sp|Q8RXN6|PRP31_ARATH U4/U6 small nuclear ribonucleoprotein Prp31 homolog; TrEMBL-Plants: tr|A0A0S3TBB0|A0A0S3TBB0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0618800 | 17 | ||
| – | U4/U6 small nuclear ribonucleoprotein Prp31; TAIR: AT1G60170.1 pre-mRNA processing ribonucleoprotein binding region-containing protein; Swiss-Prot: sp|Q8RXN6|PRP31_ARATH U4/U6 small nuclear ribonucleoprotein Prp31 homolog; TrEMBL-Plants: tr|A0A0S3TBB0|A0A0S3TBB0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0618800 | 17 | ||
| – | Nucleolar protein; TAIR: AT3G12860.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|Q3SZ63|NOP56_BOVIN Nucleolar protein 56; TrEMBL-Plants: tr|I1KJ56|I1KJ56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196600_LC | 11 | ||
| – | Nucleolar family protein; TAIR: AT1G56110.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|O94514|NOP56_SCHPO Nucleolar protein 56; TrEMBL-Plants: tr|I1KJ56|I1KJ56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196600_LC | 13 | ||
| – | Nucleolar family protein; TAIR: AT1G56110.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|O94514|NOP56_SCHPO Nucleolar protein 56; TrEMBL-Plants: tr|I1KJ56|I1KJ56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196600_LC | 13 | ||
| – | Nucleolar protein; TAIR: AT3G12860.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|Q3SZ63|NOP56_BOVIN Nucleolar protein 56; TrEMBL-Plants: tr|I1KJ56|I1KJ56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196600_LC | 11 | ||
| – | Nucleolar family protein; TAIR: AT1G56110.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|O94514|NOP56_SCHPO Nucleolar protein 56; TrEMBL-Plants: tr|I1KJ56|I1KJ56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196600_LC | 13 | ||
| – | Nucleolar protein; TAIR: AT3G12860.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|O00567|NOP56_HUMAN Nucleolar protein 56; TrEMBL-Plants: tr|I1KJ56|I1KJ56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196600_LC | 11 | ||
| – | Nucleolar family protein; TAIR: AT1G56110.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|O94514|NOP56_SCHPO Nucleolar protein 56; TrEMBL-Plants: tr|I1KJ56|I1KJ56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196600_LC | 13 | ||
| – | Nucleolar protein; TAIR: AT3G12860.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|O00567|NOP56_HUMAN Nucleolar protein 56; TrEMBL-Plants: tr|I1KJ56|I1KJ56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196600_LC | 11 | ||
| – | Nucleolar family protein; TAIR: AT1G56110.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|O94514|NOP56_SCHPO Nucleolar protein 56; TrEMBL-Plants: tr|I1KJ56|I1KJ56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196600_LC | 13 | ||
| – | Nucleolar family protein; TAIR: AT1G56110.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|O94514|NOP56_SCHPO Nucleolar protein 56; TrEMBL-Plants: tr|I1KJ56|I1KJ56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0196600_LC | 13 | ||
| – | Nucleolar protein; TAIR: AT3G05060.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|Q9MAB3|NOP5B_ARATH Probable nucleolar protein 5-2; TrEMBL-Plants: tr|Q70I27|Q70I27_LOTJA SAR DNA-binding protein-like protein; Found in the gene: LotjaGi3g1v0511600 | 18 | ||
| – | Nucleolar protein; TAIR: AT3G05060.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|Q9MAB3|NOP5B_ARATH Probable nucleolar protein 5-2; TrEMBL-Plants: tr|Q70I27|Q70I27_LOTJA SAR DNA-binding protein-like protein; Found in the gene: LotjaGi3g1v0511600 | 18 | ||
| – | Nucleolar family protein; TAIR: AT1G56110.1 NOP56-like pre RNA processing ribonucleoprotein; Swiss-Prot: sp|O94514|NOP56_SCHPO Nucleolar protein 56; TrEMBL-Plants: tr|I3S8I2|I3S8I2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0223200 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 4.55 |