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IPR027105 is a U4/U6 small nuclear ribonucleoprotein Prp31.
<p>Prp31 is a component of the U4/U6-U5 snRNP complex that is involved in pre-mRNA splicing [[cite:PUB00044450]]. It is required for U4/U6.U5 tri-snRNP formation [[cite:PUB00062922], [cite:PUB00004465]]. Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11). RP leads to degeneration of retinal photoreceptor cells [[cite:PUB00062919], [cite:PUB00062920], [cite:PUB00062921]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Spliceosomal tri-snRNP complex assembly | The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. | ||
| Biological process | MRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. | ||
| Cellular component | U4/U6 x U5 tri-snRNP complex | A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: U4/U6 small nuclear ribonucleoprotein Prp31-like isoform X2 [Cicer arietinum] gi|502100538|ref|XP_004491744.1| | 11 | ||
| – | PREDICTED: U4/U6 small nuclear ribonucleoprotein Prp31-like isoform X1 [Cicer arietinum] gi|502100534|ref|XP_004491743.1| | 3 | ||
| – | PREDICTED: U4/U6 small nuclear ribonucleoprotein Prp31-like [Glycine max] gi|356571467|ref|XP_003553898.1| | 5 | ||
| – | U4/U6 small nuclear ribonucleoprotein Prp31; TAIR: AT1G60170.1 pre-mRNA processing ribonucleoprotein binding region-containing protein; Swiss-Prot: sp|Q8RXN6|PRP31_ARATH U4/U6 small nuclear ribonucleoprotein Prp31 homolog; TrEMBL-Plants: tr|A0A0S3TBB0|A0A0S3TBB0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0618800 | 17 | ||
| – | U4/U6 small nuclear ribonucleoprotein Prp31; TAIR: AT1G60170.1 pre-mRNA processing ribonucleoprotein binding region-containing protein; Swiss-Prot: sp|Q8RXN6|PRP31_ARATH U4/U6 small nuclear ribonucleoprotein Prp31 homolog; TrEMBL-Plants: tr|I1MLN7|I1MLN7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0618800 | 4 | ||
| – | U4/U6 small nuclear ribonucleoprotein Prp31; TAIR: AT1G60170.1 pre-mRNA processing ribonucleoprotein binding region-containing protein; Swiss-Prot: sp|Q8RXN6|PRP31_ARATH U4/U6 small nuclear ribonucleoprotein Prp31 homolog; TrEMBL-Plants: tr|A0A0S3TBB0|A0A0S3TBB0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0618800 | 17 | ||
| – | U4/U6 small nuclear ribonucleoprotein Prp31; TAIR: AT1G60170.1 pre-mRNA processing ribonucleoprotein binding region-containing protein; Swiss-Prot: sp|Q8RXN6|PRP31_ARATH U4/U6 small nuclear ribonucleoprotein Prp31 homolog; TrEMBL-Plants: tr|A0A0S3TBB0|A0A0S3TBB0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0618800 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 14.29 |