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IPR002711

Source: InterPro

Description

IPR002711 is a HNH endonuclease.

<p>HNH endonuclease is found in bacteria and viruses [[cite:PUB00004482], [cite:PUB00005727], [cite:PUB00005734]]. This entry represents the catalytic core of these enzymes that folds into a typical ββα-fold [[cite:PUB00103794]]. It spans the conserved catalytic HNH motif and the Zn-binding site. This minimal catalytic core is found in site-specific homing endonucleases, restriction enzymes, pyocins, colicins and anaredoxins. Bacterial HNH domains are known to act as both site-specific DNA nucleases (in homing nucleases for example, or in the RNA-guided DNA endonuclease Cas9), as well as non-specific nucleases (in colicins, a subgroup of bacterial toxins) [[cite:PUB00068885]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003676
Molecular function Nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
Subterm of
GO:0004519
Molecular function Endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj0g3v0322239.1
– PREDICTED: zinc finger Ran-binding domain-containing protein 3-like [Glycine max] gi|356519100|ref|XP_003528212.1|
Domains
14
Lj0g3v0322239.2
– PREDICTED: zinc finger Ran-binding domain-containing protein 3-like [Glycine max] gi|356519100|ref|XP_003528212.1|
Domains
14
Lj0g3v0322239.3
– PREDICTED: zinc finger Ran-binding domain-containing protein 3-like [Glycine max] gi|356519100|ref|XP_003528212.1|
Domains
21
Lj0g3v0322239.4
– PREDICTED: zinc finger Ran-binding domain-containing protein 3-like [Glycine max] gi|356519100|ref|XP_003528212.1|
Domains
14
LotjaGi1g1v0191200.1
– DNA/RNA helicase protein; TAIR: AT5G07810.1 SNF2 domain-containing protein / helicase domain-containing protein / HNH endonuclease domain-containing protein; Swiss-Prot: sp|Q6NZP1|ZRAB3_MOUSE DNA annealing helicase and endonuclease ZRANB3; TrEMBL-Plants: tr|V7CJZ0|V7CJZ0_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0191200
Domains
24
LotjaGi4g1v0250000.1
– HNH endonuclease; TAIR: AT3G47490.1 HNH endonuclease; Swiss-Prot: sp|Q96F46|I17RA_HUMAN Interleukin-17 receptor A; TrEMBL-Plants: tr|I3T7Q3|I3T7Q3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0250000
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67