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IPR002932 is a Glutamate synthase domain.
<p>Ferredoxin-dependent glutamate synthase (GltS) has been implicated in a number of functions including photorespiration in Arabidopsis where it may also play a role in primary nitrogen assimilation in roots [[cite:PUB00007209]]. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centres, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor [[cite:PUB00080763], [cite:PUB00043791], [cite:PUB00080764]].</p> <p>This domain is expressed as a separate subunit in the glutamate synthase alpha subunit from archaebacteria, or part of a large multidomain enzyme in other organisms. It contains a putative FMN binding site and Fe-S cluster [[cite:PUB00015747], [cite:PUB00005657]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Glutamate biosynthetic process | The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. | ||
| Molecular function | Glutamate synthase activity | Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. | ||
| Molecular function | Oxidoreductase activity, acting on the CH-NH2 group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: glutamate synthase [NADH] gi|356571346|ref|XP_003553839.1| | 24 | ||
| – | NADH glutamate synthase precursor [Phaseolus vulgaris] gi|62177687|gb|AAL26865.2|AF314925_1 | 14 | ||
| – | PREDICTED: ferredoxin-dependent glutamate synthase 1, chloroplastic-like isoform X1 [Cicer arietinum] gi|502108182|ref|XP_004493407.1| | 21 | ||
| – | PREDICTED: ferredoxin-dependent glutamate synthase 1, chloroplastic-like isoform X1 [Cicer arietinum] gi|502108182|ref|XP_004493407.1| | 11 | ||
| – | Ferredoxin-dependent glutamate synthase [Glycine max] gi|2773270|gb|AAB96761.1| | 7 | ||
| – | Ferredoxin-dependent glutamate synthase [Glycine max] gi|2773270|gb|AAB96761.1| | 12 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A0B2SWZ8|A0A0B2SWZ8_GLYSO Glutamate synthase [NADH], amyloplastic; Found in the gene: LotjaGi1g1v0224700 | 40 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A072VE66|A0A072VE66_MEDTR NADH glutamate synthase; Found in the gene: LotjaGi1g1v0224700 | 36 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A072VE66|A0A072VE66_MEDTR NADH glutamate synthase; Found in the gene: LotjaGi1g1v0224700 | 23 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A0B2SWZ8|A0A0B2SWZ8_GLYSO Glutamate synthase [NADH], amyloplastic; Found in the gene: LotjaGi1g1v0224700 | 40 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A072VE66|A0A072VE66_MEDTR NADH glutamate synthase; Found in the gene: LotjaGi1g1v0224700 | 45 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A0B2SWZ8|A0A0B2SWZ8_GLYSO Glutamate synthase [NADH], amyloplastic; Found in the gene: LotjaGi1g1v0224700 | 37 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A0B2SWZ8|A0A0B2SWZ8_GLYSO Glutamate synthase [NADH], amyloplastic; Found in the gene: LotjaGi1g1v0224700 | 40 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A0S3RN10|A0A0S3RN10_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0224700 | 40 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|Q93WZ7|Q93WZ7_PHAVU NADH glutamate synthase; Found in the gene: LotjaGi1g1v0224700 | 28 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A0B2SLS9|A0A0B2SLS9_GLYSO Glutamate synthase [NADH], amyloplastic; Found in the gene: LotjaGi1g1v0224700 | 23 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A072VE66|A0A072VE66_MEDTR NADH glutamate synthase; Found in the gene: LotjaGi1g1v0224700 | 30 | ||
| – | Glutamate synthase, putative; TAIR: AT5G53460.1 NADH-dependent glutamate synthase 1; Swiss-Prot: sp|Q03460|GLSN_MEDSA Glutamate synthase [NADH], amyloplastic; TrEMBL-Plants: tr|A0A072VE66|A0A072VE66_MEDTR NADH glutamate synthase; Found in the gene: LotjaGi1g1v0224700 | 45 | ||
| – | Glutamate synthase, putative; TAIR: AT5G04140.1 glutamate synthase 1; Swiss-Prot: sp|Q43155|GLTB_SPIOL Ferredoxin-dependent glutamate synthase, chloroplastic; TrEMBL-Plants: tr|A0A151RUY7|A0A151RUY7_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0664300 | 29 | ||
| – | Glutamate synthase, putative; TAIR: AT5G04140.1 glutamate synthase 1; Swiss-Prot: sp|Q43155|GLTB_SPIOL Ferredoxin-dependent glutamate synthase, chloroplastic; TrEMBL-Plants: tr|A0A151RUY7|A0A151RUY7_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0664300 | 24 | ||
| – | Glutamate synthase, putative; TAIR: AT5G04140.1 glutamate synthase 1; Swiss-Prot: sp|Q43155|GLTB_SPIOL Ferredoxin-dependent glutamate synthase, chloroplastic; TrEMBL-Plants: tr|A0A0E0QC77|A0A0E0QC77_ORYRU Uncharacterized protein; Found in the gene: LotjaGi1g1v0664300 | 24 | ||
| – | Glutamate synthase, putative; TAIR: AT5G04140.1 glutamate synthase 1; Swiss-Prot: sp|Q43155|GLTB_SPIOL Ferredoxin-dependent glutamate synthase, chloroplastic; TrEMBL-Plants: tr|A0A0E0QC77|A0A0E0QC77_ORYRU Uncharacterized protein; Found in the gene: LotjaGi1g1v0664300 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 4.55 |