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IPR003084 is a Histone deacetylase.
<p>Regulation of transcription is, in part, modulated by reversible histone acetylation on several lysine. Histone deacetylases (HDA) catalyse the removal of the acetyl group. Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are all members of this ancient protein superfamily [[cite:PUB00004480]].</p> <p>HDAs function in multi-subunit complexes, reversing the acetylation of histones by histone acetyltransferases [[cite:PUB00006504], [cite:PUB00006434]], and are also believed to deacetylate general transcription factors such as TFIIF and sequence-specific transcription factors such as p53 [[cite:PUB00006504]]. Thus, HDAs contribute to the regulation of transcription, in particular transcriptional repression [[cite:PUB00006434]]. At N-terminal tails of histones, removal of the acetyl group from the ε-amino group of a lysine side chain will restore its positivecharge, which may stabilise the histone-DNA interaction and prevent activating transcription factors binding to promoter elements [[cite:PUB00004480]]. HDAs play important roles in the cell cycle and differentiation, and their deregulation can contribute to the development of cancer [[cite:PUB00006434], [cite:PUB00006562]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Histone deacetylase activity | Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. | ||
Biological process | Histone deacetylation | The modification of histones by removal of acetyl groups. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Histone deacetylase 6 isoform 2 [Theobroma cacao] gi|508773583|gb|EOY20839.1| | 10 | ||
– | PREDICTED: histone deacetylase 19-like [Glycine max] gi|356551138|ref|XP_003543935.1| | 13 | ||
– | PREDICTED: histone deacetylase 19-like [Glycine max] gi|356551138|ref|XP_003543935.1| | 12 | ||
– | Histone deacetylase 6 isoform 2 [Theobroma cacao] gi|508773583|gb|EOY20839.1| | 15 | ||
– | Histone deacetylase [Medicago truncatula] gi|357461841|ref|XP_003601202.1| | 13 | ||
– | Histone deacetylase 9 isoform 11 [Theobroma cacao] gi|508786277|gb|EOY33533.1| | 11 | ||
– | PREDICTED: histone deacetylase 9-like [Cicer arietinum] gi|502145712|ref|XP_004506146.1| | 12 | ||
– | PREDICTED: histone deacetylase 6-like [Glycine max] gi|356513715|ref|XP_003525556.1| | 13 | ||
– | PREDICTED: histone deacetylase 6-like [Glycine max] gi|356513715|ref|XP_003525556.1| | 13 | ||
– | Histone deacetylase; TAIR: AT4G38130.1 histone deacetylase 1; Swiss-Prot: sp|O22446|HDA19_ARATH Histone deacetylase 19; TrEMBL-Plants: tr|I1LWR2|I1LWR2_SOYBN Histone deacetylase; Found in the gene: LotjaGi1g1v0146200 | 14 | ||
– | Histone deacetylase; TAIR: AT4G38130.1 histone deacetylase 1; Swiss-Prot: sp|O22446|HDA19_ARATH Histone deacetylase 19; TrEMBL-Plants: tr|I1LWR2|I1LWR2_SOYBN Histone deacetylase; Found in the gene: LotjaGi1g1v0146200 | 14 | ||
– | Histone deacetylase; TAIR: AT4G38130.1 histone deacetylase 1; Swiss-Prot: sp|O22446|HDA19_ARATH Histone deacetylase 19; TrEMBL-Plants: tr|I1LWR2|I1LWR2_SOYBN Histone deacetylase; Found in the gene: LotjaGi1g1v0146200 | 14 | ||
– | Histone deacetylase; TAIR: AT4G38130.1 histone deacetylase 1; Swiss-Prot: sp|O22446|HDA19_ARATH Histone deacetylase 19; TrEMBL-Plants: tr|I1LWR2|I1LWR2_SOYBN Histone deacetylase; Found in the gene: LotjaGi1g1v0146200 | 14 | ||
– | Histone deacetylase; TAIR: AT4G38130.1 histone deacetylase 1; Swiss-Prot: sp|O22446|HDA19_ARATH Histone deacetylase 19; TrEMBL-Plants: tr|I1LWR2|I1LWR2_SOYBN Histone deacetylase; Found in the gene: LotjaGi1g1v0146200 | 14 | ||
– | Histone deacetylase; TAIR: AT4G38130.1 histone deacetylase 1; Swiss-Prot: sp|O22446|HDA19_ARATH Histone deacetylase 19; TrEMBL-Plants: tr|A0A151RPJ3|A0A151RPJ3_CAJCA Histone deacetylase; Found in the gene: LotjaGi1g1v0146200 | 13 | ||
– | Histone deacetylase; TAIR: AT5G63110.1 histone deacetylase 6; Swiss-Prot: sp|Q9FML2|HDA6_ARATH Histone deacetylase 6; TrEMBL-Plants: tr|G7J4T5|G7J4T5_MEDTR Histone deacetylase; Found in the gene: LotjaGi1g1v0176200 | 15 | ||
– | Histone deacetylase; TAIR: AT5G63110.1 histone deacetylase 6; Swiss-Prot: sp|Q9FML2|HDA6_ARATH Histone deacetylase 6; TrEMBL-Plants: tr|G7J4T5|G7J4T5_MEDTR Histone deacetylase; Found in the gene: LotjaGi1g1v0176200 | 15 | ||
– | Histone deacetylase; TAIR: AT3G44680.1 histone deacetylase 9; Swiss-Prot: sp|Q8H0W2|HDA9_ARATH Histone deacetylase 9; TrEMBL-Plants: tr|A0A151TNQ1|A0A151TNQ1_CAJCA Histone deacetylase; Found in the gene: LotjaGi3g1v0479900 | 14 | ||
– | Histone deacetylase; TAIR: AT3G44680.1 histone deacetylase 9; Swiss-Prot: sp|Q8H0W2|HDA9_ARATH Histone deacetylase 9; TrEMBL-Plants: tr|A0A151TNQ1|A0A151TNQ1_CAJCA Histone deacetylase; Found in the gene: LotjaGi3g1v0479900 | 14 | ||
– | Histone deacetylase; TAIR: AT3G44680.1 histone deacetylase 9; Swiss-Prot: sp|Q8H0W2|HDA9_ARATH Histone deacetylase 9; TrEMBL-Plants: tr|A0A151TNQ1|A0A151TNQ1_CAJCA Histone deacetylase; Found in the gene: LotjaGi3g1v0479900 | 13 | ||
– | Histone deacetylase; TAIR: AT3G44680.1 histone deacetylase 9; Swiss-Prot: sp|Q8H0W2|HDA9_ARATH Histone deacetylase 9; TrEMBL-Plants: tr|A0A151TNQ1|A0A151TNQ1_CAJCA Histone deacetylase; Found in the gene: LotjaGi3g1v0479900 | 13 | ||
– | Histone deacetylase; TAIR: AT3G44680.1 histone deacetylase 9; Swiss-Prot: sp|Q8H0W2|HDA9_ARATH Histone deacetylase 9; TrEMBL-Plants: tr|A0A151TNQ1|A0A151TNQ1_CAJCA Histone deacetylase; Found in the gene: LotjaGi3g1v0479900 | 13 | ||
– | Histone deacetylase; TAIR: AT5G63110.1 histone deacetylase 6; Swiss-Prot: sp|Q9FML2|HDA6_ARATH Histone deacetylase 6; TrEMBL-Plants: tr|A0A0S3R6F7|A0A0S3R6F7_PHAAN Histone deacetylase; Found in the gene: LotjaGi4g1v0229800 | 15 | ||
– | Histone deacetylase; TAIR: AT5G63110.1 histone deacetylase 6; Swiss-Prot: sp|Q9FML2|HDA6_ARATH Histone deacetylase 6; TrEMBL-Plants: tr|A0A0S3R6F7|A0A0S3R6F7_PHAAN Histone deacetylase; Found in the gene: LotjaGi4g1v0229800 | 15 | ||
– | Histone deacetylase; TAIR: AT5G63110.1 histone deacetylase 6; Swiss-Prot: sp|Q9FML2|HDA6_ARATH Histone deacetylase 6; TrEMBL-Plants: tr|A0A0S3R6F7|A0A0S3R6F7_PHAAN Histone deacetylase; Found in the gene: LotjaGi4g1v0229800 | 15 | ||
– | Histone deacetylase; TAIR: AT5G63110.1 histone deacetylase 6; Swiss-Prot: sp|Q9FML2|HDA6_ARATH Histone deacetylase 6; TrEMBL-Plants: tr|A0A0L9TQL1|A0A0L9TQL1_PHAAN Histone deacetylase; Found in the gene: LotjaGi4g1v0230000 | 15 | ||
– | Histone deacetylase; TAIR: AT5G63110.1 histone deacetylase 6; Swiss-Prot: sp|Q9FML2|HDA6_ARATH Histone deacetylase 6; TrEMBL-Plants: tr|A0A0L9TQL1|A0A0L9TQL1_PHAAN Histone deacetylase; Found in the gene: LotjaGi4g1v0230000 | 15 | ||
– | Histone deacetylase; TAIR: AT5G63110.1 histone deacetylase 6; Swiss-Prot: sp|P56519|HDAC2_CHICK Histone deacetylase 2; TrEMBL-Plants: tr|A0A0L9TQL1|A0A0L9TQL1_PHAAN Histone deacetylase; Found in the gene: LotjaGi4g1v0230000 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 3.57 |