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IPR003173 is a Transcriptional coactivator p15 (PC4), C-terminal.
<p>This entry represents a ssDNA binding domain found at the C-terminal end of YdbC from Lactococcus lactis, Activated RNA polymerase II transcriptional coactivator p15 from humans and other PC4 family members.</p> <p>YdbC, which adopts a dimeric fold, shows a concave four-stranded antiparallel sheet followed by a C-terminal helix in a similar configuration to PC4 [[cite:PUB00063943]].</p> <p>p15 has a bipartite structure composed of an amino-terminal regulatory domain and a carboxy-terminal cryptic DNA-binding domain [[cite:PUB00006308], [cite:PUB00011851]]. The DNA-binding activity of the carboxy-terminal is disguised by the amino-terminal p15 domain. Activity is controlled by protein kinases that target the regulatory domain. Its interaction with the tumor suppressor protein p53 may play a role in certain neurodegenerative diseases [[cite:PUB00100871]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: RNA polymerase II transcriptional coactivator KELP-like [Cucumis sativus] gi|449462521|ref|XP_004148989.1| | 7 | ||
| – | PREDICTED: RNA polymerase II transcriptional coactivator KELP-like [Cucumis sativus] gi|449462521|ref|XP_004148989.1| | 7 | ||
| – | PREDICTED: RNA polymerase II transcriptional coactivator KELP-like [Cucumis sativus] gi|449462521|ref|XP_004148989.1| | 7 | ||
| – | PREDICTED: RNA polymerase II transcriptional coactivator KELP-like [Cucumis sativus] gi|449462521|ref|XP_004148989.1| | 16 | ||
| – | RNA polymerase II transcriptional coactivator; TAIR: AT5G09250.1 ssDNA-binding transcriptional regulator; Swiss-Prot: sp|O65154|KIWI_ARATH RNA polymerase II transcriptional coactivator KIWI; TrEMBL-Plants: tr|I3SIW1|I3SIW1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0322600 | 8 | ||
| – | RNA polymerase II transcriptional coactivator; TAIR: AT5G09250.1 ssDNA-binding transcriptional regulator; Swiss-Prot: sp|O65154|KIWI_ARATH RNA polymerase II transcriptional coactivator KIWI; TrEMBL-Plants: tr|I3SIW1|I3SIW1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0322600 | 8 | ||
| – | RNA polymerase II transcriptional coactivator KELP; TAIR: AT4G00980.1 zinc knuckle (CCHC-type) family protein; Swiss-Prot: sp|O65155|KELP_ARATH RNA polymerase II transcriptional coactivator KELP; TrEMBL-Plants: tr|A0A151TXZ1|A0A151TXZ1_CAJCA RNA polymerase II transcriptional coactivator KELP; Found in the gene: LotjaGi1g1v0793500 | 13 | ||
| – | RNA polymerase II transcriptional coactivator KELP; TAIR: AT4G10920.1 transcriptional coactivator p15 (PC4) family protein (KELP); Swiss-Prot: sp|O65155|KELP_ARATH RNA polymerase II transcriptional coactivator KELP; TrEMBL-Plants: tr|A0A151TXZ1|A0A151TXZ1_CAJCA RNA polymerase II transcriptional coactivator KELP; Found in the gene: LotjaGi1g1v0793500 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |