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IPR009044 is a ssDNA-binding transcriptional regulator.
<p>This superfamily represents a ssDNA-binding transcriptional regulator domain consisting of a helix-swapped dimer of β(4)-α motifs. This domain is found as a C-terminal domain in the transcriptional co-activator PC4 (also known as P15; where it is a dimer of two separate motifs), and in the plant transcriptional regulator PBF-2 (where it is a single chain domain formed by a tandem repeat of two motifs).</p> <p>Transcriptional regulators play a critical role in controlling the level of transcription from specific genes in response to different stimuli. Members of this family of transcriptional regulators, which preferentially bind single-stranded DNA, include PBF-2 from plants, the mammalian nuclear factor 1-X (NF1-X), and positive cofactor 4 (PC4). These proteins are structurally similar, consisting of a helix-swapped dimer of β(4)-α motifs.</p> <p>The plant defence transcription factor PBF-2 is comprised of four p24 subunits that interact through a helix-loop-helix motif to produce a central pore [[cite:PUB00011849]]. PBF-2 functions as part of the plant's defence system in response to the detection of a pathogen. Upon stimulation, PBF-2 induces several signal transduction pathways leading to changes in the expression of defence genes, including the pathogenesis-related (PR) genes.</p> <p>NF1-X is one of several NF1 proteins that function as transcription factors. NF1-X consists of two functionally distinct domains: a conserved N-terminal DNA-binding domain and a C-terminal transcriptional regulatory domain. NF1-X binds to the promoter for the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase gene [[cite:PUB00011850]].</p> <p>PC4 (or P15) possess the ability to co-activate and suppress transcription via its DNA-binding activity. PC4 has been shown to stimulate transcription<i>in vitro</i>with diverse activators, including VP16, thyroid hormone receptor, BRCA-1, often involving TFIIA. PC4 and TFIIA are thought to facilitate the assembly of the pre-initiation complex. The repressive activity of PC4 can be alleviated by the transcription factor TFIIH, which protects promoters from PC4 repression [[cite:PUB00011852]]. PC4 consists of two domains: an N-terminal regulatory domain and a C-terminal cryptic DNA-binding domain. The protein acts as a dimer with two ssDNA binding channels running in opposite directions to each other [[cite:PUB00011851]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: single-stranded DNA-binding protein WHY1, chloroplastic-like isoform X1 [Cicer arietinum] gi|502093648|ref|XP_004490008.1| | 7 | ||
| – | PREDICTED: single-stranded DNA-binding protein WHY1, chloroplastic-like isoform X1 [Cicer arietinum] gi|502093648|ref|XP_004490008.1| | 7 | ||
| – | PREDICTED: RNA polymerase II transcriptional coactivator KELP-like [Cucumis sativus] gi|449462521|ref|XP_004148989.1| | 7 | ||
| – | PREDICTED: single-stranded DNA-binding protein WHY1, chloroplastic-like [Cicer arietinum] gi|502170191|ref|XP_004514779.1| | 8 | ||
| – | PREDICTED: RNA polymerase II transcriptional coactivator KELP-like [Cucumis sativus] gi|449462521|ref|XP_004148989.1| | 7 | ||
| – | PREDICTED: single-stranded DNA-bindig protein WHY2, mitochondrial-like [Cicer arietinum] gi|502113776|ref|XP_004494755.1| | 7 | ||
| – | PREDICTED: RNA polymerase II transcriptional coactivator KELP-like [Cucumis sativus] gi|449462521|ref|XP_004148989.1| | 7 | ||
| – | PREDICTED: RNA polymerase II transcriptional coactivator KELP-like [Cucumis sativus] gi|449462521|ref|XP_004148989.1| | 16 | ||
| – | RNA polymerase II transcriptional coactivator; TAIR: AT5G09250.1 ssDNA-binding transcriptional regulator; Swiss-Prot: sp|O65154|KIWI_ARATH RNA polymerase II transcriptional coactivator KIWI; TrEMBL-Plants: tr|I3SIW1|I3SIW1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0322600 | 8 | ||
| – | RNA polymerase II transcriptional coactivator; TAIR: AT5G09250.1 ssDNA-binding transcriptional regulator; Swiss-Prot: sp|O65154|KIWI_ARATH RNA polymerase II transcriptional coactivator KIWI; TrEMBL-Plants: tr|I3SIW1|I3SIW1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0322600 | 8 | ||
| – | Single-stranded DNA-binding protein WHY3; TAIR: AT1G71260.1 WHIRLY 2; Swiss-Prot: sp|Q8VYF7|WHY2_ARATH Single-stranded DNA-binding protein WHY2, mitochondrial; TrEMBL-Plants: tr|I3SAE2|I3SAE2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0786600 | 7 | ||
| – | RNA polymerase II transcriptional coactivator KELP; TAIR: AT4G00980.1 zinc knuckle (CCHC-type) family protein; Swiss-Prot: sp|O65155|KELP_ARATH RNA polymerase II transcriptional coactivator KELP; TrEMBL-Plants: tr|A0A151TXZ1|A0A151TXZ1_CAJCA RNA polymerase II transcriptional coactivator KELP; Found in the gene: LotjaGi1g1v0793500 | 13 | ||
| – | RNA polymerase II transcriptional coactivator KELP; TAIR: AT4G10920.1 transcriptional coactivator p15 (PC4) family protein (KELP); Swiss-Prot: sp|O65155|KELP_ARATH RNA polymerase II transcriptional coactivator KELP; TrEMBL-Plants: tr|A0A151TXZ1|A0A151TXZ1_CAJCA RNA polymerase II transcriptional coactivator KELP; Found in the gene: LotjaGi1g1v0793500 | 12 | ||
| – | Single-stranded DNA-binding protein WHY1, chloroplastic; TAIR: AT1G14410.1 ssDNA-binding transcriptional regulator; Swiss-Prot: sp|Q9M9S3|WHY1_ARATH Single-stranded DNA-binding protein WHY1, chloroplastic; TrEMBL-Plants: tr|A0A0L9TLQ1|A0A0L9TLQ1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0307700 | 7 | ||
| – | Single-stranded DNA-binding protein WHY1, chloroplastic; TAIR: AT1G14410.1 ssDNA-binding transcriptional regulator; Swiss-Prot: sp|Q9M9S3|WHY1_ARATH Single-stranded DNA-binding protein WHY1, chloroplastic; TrEMBL-Plants: tr|A0A0L9TLQ1|A0A0L9TLQ1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0307700 | 7 | ||
| – | Single-stranded DNA-binding protein WHY1, chloroplastic; TAIR: AT1G14410.1 ssDNA-binding transcriptional regulator; Swiss-Prot: sp|Q9M9S3|WHY1_ARATH Single-stranded DNA-binding protein WHY1, chloroplastic; TrEMBL-Plants: tr|A0A0L9TLQ1|A0A0L9TLQ1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0307700 | 7 | ||
| – | Single-stranded dna-binding protein why1, chloroplastic; TAIR: AT1G14410.1 ssDNA-binding transcriptional regulator; Swiss-Prot: sp|Q9M9S3|WHY1_ARATH Single-stranded DNA-binding protein WHY1, chloroplastic; TrEMBL-Plants: tr|I3SQW0|I3SQW0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0187200 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SignalP-TM | SignalP_GRAM_NEGATIVE | 1 | 5.88 |