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IPR004152 is a GAT domain.
<p>The GAT domain is a region of homology of ~130 residues, which is found in eukaryotic GGAs (for Golgi-localized, gamma ear-containing ADP ribosylation factor (ARF)-binding proteins) and vertebrate TOMs (for target of myb). The GAT domain is found in its entirety only in GGAs, although, at the C terminus it shares partial sequence similarity with a short region of TOMs. The GAT domain is found in association with other domains, such as VHS and GAE. The GAT domain of GGAs serves as a molecular anchor of GGA to trans-Golgi network (TGN) membranes via its interaction with the GTP-bound form of a member of the ARF family of small GTPases and can bind specifically to the Rab GTPase effector rabaptin5 and to ubiquitin [[cite:PUB00007389], [cite:PUB00018380], [cite:PUB00018381], [cite:PUB00018382]].</p> <p>The GGA-GAT domain possesses an all α-helical structure, composed of four helices arranged in a somewhat unusual topology, which has been called the helical paper clip. The overall structure shows that the GAT domain has an elongated shape, in which the longest helix participates in two small independent subdomains: an N-terminal helix-loop-helix hook and a C-terminal three-helix bundle. The hook subdomain has been shown to be both necessary and sufficient for ARF-GTP binding and Golgi targeting of GGAs. The N-terminal hook subdomain contains a hydrophobic patch, which is found to interact directly with ARF [[cite:PUB00018380]]. It has been proposed that this interaction might stabilise the hook subdomain [[cite:PUB00018381]]. The C-terminal three-helix bundle is involved in the binding with Rabaptin5 and ubiquitin [[cite:PUB00018382]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Biological process | Intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: TOM1-like protein 2-like [Glycine max] gi|356509355|ref|XP_003523415.1| | 16 | ||
– | PREDICTED: target of Myb protein 1-like [Glycine max] gi|356570650|ref|XP_003553498.1| | 13 | ||
– | PREDICTED: TOM1-like protein 2-like [Cicer arietinum] gi|502159182|ref|XP_004511421.1| | 18 | ||
– | PREDICTED: TOM1-like protein 2-like [Glycine max] gi|356509355|ref|XP_003523415.1| | 19 | ||
– | PREDICTED: target of Myb protein 1-like [Cicer arietinum] gi|502137213|ref|XP_004503010.1| | 18 | ||
– | PREDICTED: TOM1-like protein 1-like [Glycine max] gi|356507893|ref|XP_003522697.1| | 17 | ||
– | PREDICTED: TOM1-like protein 2-like [Glycine max] gi|356530201|ref|XP_003533672.1| | 15 | ||
– | PREDICTED: target of Myb protein 1-like [Glycine max] gi|356570650|ref|XP_003553498.1| | 16 | ||
– | PREDICTED: target of Myb protein 1-like [Glycine max] gi|356570650|ref|XP_003553498.1| | 16 | ||
– | PREDICTED: TOM1-like protein 2 [Vitis vinifera] gi|225461774|ref|XP_002285602.1| | 19 | ||
– | PREDICTED: target of Myb protein 1-like [Glycine max] gi|356516423|ref|XP_003526894.1| | 17 | ||
– | TOM1-like protein 2; TAIR: AT1G21380.1 Target of Myb protein 1; Swiss-Prot: sp|Q5SRX1|TM1L2_MOUSE TOM1-like protein 2; TrEMBL-Plants: tr|A0A0S3RDF2|A0A0S3RDF2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0165000 | 20 | ||
– | TOM1-like protein 2; TAIR: AT1G21380.1 Target of Myb protein 1; Swiss-Prot: sp|Q68FJ8|TM1L2_XENLA TOM1-like protein 2; TrEMBL-Plants: tr|A0A0L9UFL9|A0A0L9UFL9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0270600 | 20 | ||
– | ENTH/VHS/GAT family protein; TAIR: AT5G63640.1 ENTH/VHS/GAT family protein; Swiss-Prot: sp|Q99LI8|HGS_MOUSE Hepatocyte growth factor-regulated tyrosine kinase substrate; TrEMBL-Plants: tr|A0A0L9UDW3|A0A0L9UDW3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0328000 | 19 | ||
– | TOM1-like protein 2; TAIR: AT4G32760.1 ENTH/VHS/GAT family protein; Swiss-Prot: sp|Q68FJ8|TM1L2_XENLA TOM1-like protein 2; TrEMBL-Plants: tr|A0A0B2PRM5|A0A0B2PRM5_GLYSO TOM1-like protein 2; Found in the gene: LotjaGi1g1v0401200 | 18 | ||
– | TOM1-like protein 2; TAIR: AT2G38410.1 ENTH/VHS/GAT family protein; Swiss-Prot: sp|Q68FJ8|TM1L2_XENLA TOM1-like protein 2; TrEMBL-Plants: tr|G7KW31|G7KW31_MEDTR ENTH/VHS/GAT family protein; Found in the gene: LotjaGi1g1v0452100 | 18 | ||
– | TOM1-like protein 2; TAIR: AT1G06210.1 ENTH/VHS/GAT family protein; Swiss-Prot: sp|P0CR79|HSE1_CRYNB Class E vacuolar protein-sorting machinery protein HSE1; TrEMBL-Plants: tr|I1N9R3|I1N9R3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0701400_LC | 15 | ||
– | TOM1-like protein 2; TAIR: AT1G06210.1 ENTH/VHS/GAT family protein; Swiss-Prot: sp|Q54GH3|TOM1_DICDI Target of Myb protein 1; TrEMBL-Plants: tr|I1N9R3|I1N9R3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0708900 | 17 | ||
– | TOM1-like protein 2; TAIR: AT5G16880.1 Target of Myb protein 1; Swiss-Prot: sp|Q5SRX1|TM1L2_MOUSE TOM1-like protein 2; TrEMBL-Plants: tr|A0A151SD01|A0A151SD01_CAJCA TOM1-like protein 2; Found in the gene: LotjaGi2g1v0450500 | 20 | ||
– | TOM1-like protein 2; TAIR: AT5G16880.1 Target of Myb protein 1; Swiss-Prot: sp|Q5SRX1|TM1L2_MOUSE TOM1-like protein 2; TrEMBL-Plants: tr|A0A0L9TAI5|A0A0L9TAI5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0542400 | 20 | ||
– | ENTH/VHS/GAT family protein; TAIR: AT5G63640.1 ENTH/VHS/GAT family protein; Swiss-Prot: sp|Q99LI8|HGS_MOUSE Hepatocyte growth factor-regulated tyrosine kinase substrate; TrEMBL-Plants: tr|A0A0L9UDW3|A0A0L9UDW3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0415700 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 4.76 |