Description

IPR004539 is a Translation elongation factor EF1A, eukaryotic/archaeal.

<p>Translation elongation factors are responsible for two main processes during protein synthesis on the ribosome [[cite:PUB00033953], [cite:PUB00033952], [cite:PUB00033951]]. EF1A (or EF-Tu) is responsible for the selection and binding of the cognate aminoacyl-tRNA to the A-site (acceptor site) of the ribosome. EF2 (or EF-G) is responsible for the translocation of the peptidyl-tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind. Elongation factors are responsible for achieving accuracy of translation and both EF1A and EF2 are remarkably conserved throughout evolution.</p> <p>EF-Tu (also known as EF-1alpha or EF1A) is a G-protein. It forms a ternary complex of EF-Tu (EF1A)-GTP-aminoacyltRNA. The binding of aminoacyl-tRNA stimulates GTP hydrolysis by EF-Tu (EF1A), causing a conformational change in EF-Tu (EF1A) that causes EF-Tu (EF1A)-GDP to detach from the ribosome, leaving the aminoacyl-tRNA attached at the A-site. Only the cognate aminoacyl-tRNA can induce the required conformational change in EF-Tu (EF1A) through its tight anticodon-codon binding [[cite:PUB00033960], [cite:PUB00033961]]. EF-Tu (EF1A)-GDP is returned to its active state, EF-Tu (EF1A)-GTP, through the action of another elongation factor, EF1B (also known as EF-Ts or EF-1beta/gamma/delta).</p> <p>This entry represents EF1A proteins from in eukaryotic (eEF1alpha) and archaeal (aEF1alpha) organisms, these proteins being more closely related to one another than to EF1A (or EF-Tu) from bacteria ([interpro:IPR004541]).</p> <p>Archaeal EF1-alpha is not only involved in translation elongation. It interacts with Pelota, a mRNA surveillance protein involved in no-go mRNA decay and non-stop mRNA decay; and with RF1, a tRNA-mimicking protein which recognises stop codons and catalyses polypeptide-chain release. Through these interactions archaeal EF1-alpha also has a role in translational termination and mRNA surveillance pathways [[cite:PUB00070083]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: