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IPR004588 is a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type.
<p>This protein previously of unknown biochemical function is essential in Escherichia coli. It has now been characterised as 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, which converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4CPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate in the sixth step of nonmevalonate terpenoid biosynthesis. The family is largely restricted to bacteria, where it is widely but not universally distributed. No homology can be detected between this family and other proteins.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Terpenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. | ||
| Molecular function | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity | Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase-like [Glycine max] gi|356550161|ref|XP_003543457.1| | 8 | ||
| – | PREDICTED: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase-like [Glycine max] gi|356550161|ref|XP_003543457.1| | 3 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300 | 13 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300 | 13 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|I1M4L1|I1M4L1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0162300 | 11 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00612 | TIGRFAM | 1 | 16.67 |