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IPR017178 is a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, atypical.
<p>This entry includes 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, which converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4CPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate in the sixth step of nonmevalonate terpenoid biosynthesis. It is essential in Escherichia coli. The enzyme is described as "atypical" because it contains a partially-duplicated domain. The family is found in bacteria, where it is widely but not universally distributed, and chloroplasts, where it is essential for chloroplast development [[cite:PUB00085129]], salicylic acid-mediated disease resistance to pathogens [[cite:PUB00085130]] and requires ferrdoxin as a co-factor [[cite:PUB00085131]]. No homology can be detected between this family and other proteins.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Iron ion binding | Interacting selectively and non-covalently with iron (Fe) ions. | ||
| Biological process | Isoprenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. | ||
| Molecular function | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity | Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase-like [Glycine max] gi|356550161|ref|XP_003543457.1| | 8 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300 | 13 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300 | 13 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|I1M4L1|I1M4L1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0162300 | 11 | ||
| – | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00612 | TIGRFAM | 1 | 20.00 |