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IPR005263

Source: InterPro

Description

IPR005263 is a 4-hydroxy-tetrahydrodipicolinate synthase, DapA.

<p>4-hydroxy-tetrahydrodipicolinate synthase dapA is a homotetrameric enzyme of lysine biosynthesis. It catalyses the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA) [[cite:PUB00014558]]. E. coli has several paralogs closely related to dihydrodipicoline synthase, as well as the more distant N-acetylneuraminate lyase.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008840
Molecular function 4-hydroxy-tetrahydrodipicolinate synthase Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O.
Subterm of
GO:0009089
Biological process Lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate.
Subterm of

Associated Lotus transcripts 9

Transcript Name Description Predicted domains Domain count
Lj3g3v2723870.1
– PREDICTED: 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic-like [Cicer arietinum] gi|502157868|ref|XP_004510938.1|
Domains
14
Lj3g3v2723890.1
– PREDICTED: dihydrodipicolinate synthase 2, chloroplastic-like [Glycine max] gi|356505643|ref|XP_003521599.1|
Domains
14
LotjaGi1g1v0463600.1
– 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42800|DAPA_SOYBN 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I1L6T8|I1L6T8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0463600
Domains
17
LotjaGi1g1v0463600.2
– 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42800|DAPA_SOYBN 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I1L6T8|I1L6T8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0463600
Domains
18
LotjaGi1g1v0463600.4
– 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT3G60880.1 dihydrodipicolinate synthase 1; Swiss-Prot: sp|Q42800|DAPA_SOYBN 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|G7L0A3|G7L0A3_MEDTR 4-hydroxy-tetrahydrodipicolinate synthase; Found in the gene: LotjaGi1g1v0463600
Domains
17
LotjaGi3g1v0431700.1
– 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42948|DAPA_TOBAC 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I1JKK4|I1JKK4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0431700
Domains
11
LotjaGi3g1v0431700.2
– 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42800|DAPA_SOYBN 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I3S7Q6|I3S7Q6_LOTJA 4-hydroxy-tetrahydrodipicolinate synthase; Found in the gene: LotjaGi3g1v0431700
Domains
13
LotjaGi3g1v0431800.1
– 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42948|DAPA_TOBAC 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|A0A151TBN5|A0A151TBN5_CAJCA 4-hydroxy-tetrahydrodipicolinate synthase; Found in the gene: LotjaGi3g1v0431800
Domains
14
LotjaGi3g1v0431900.1
– 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42948|DAPA_TOBAC 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I1JKK4|I1JKK4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0431900
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00950 CDD 1 11.11