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IPR002220 is a DapA-like.
<p>Dihydrodipicolinate synthase ([ec:4.2.1.52]) (DHDPS, DapA) catalyses, in higher plants, some fungi and bacteria (gene dapA), the first reaction specific to the biosynthesis of lysine and of diaminopimelate [[cite:PUB00067366]]. DHDPS is responsible for the condensation of aspartate semialdehyde and pyruvate by a ping-pong mechanism in which pyruvate first binds to the enzyme by forming a Schiff-base with a lysine residue [[cite:PUB00000520], [cite:PUB00067367]].</p> <p>Other proteins are structurally related to DHDPS and probably also act via a similar catalytic mechanism [[cite:PUB00024869]]:</p> <ul> <li>Escherichia coli N-acetylneuraminate lyase (EC 4.1.3.3) (gene nanA), which catalyses the condensation of N-acetyl-D-mannosamine and pyruvate to form N-acetylneuraminate.</li> <li>Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase.</li> <li>D-4-deoxy-5-oxoglucarate dehydratase.</li> <li>Rhizobium meliloti protein mosA [[cite:PUB00002226]], which is involved in the biosynthesis of the rhizopine 3-o-methyl-scyllo-inosamine.</li> <li>Thermoproteus tenax 2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase (KdgA) [[cite:PUB00049291]].</li></ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Lyase activity | Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dihydrodipicolinate synthase 2, chloroplastic-like [Glycine max] gi|356505643|ref|XP_003521599.1| | 12 | ||
| – | PREDICTED: 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic-like [Cicer arietinum] gi|502104773|ref|XP_004492645.1| | 14 | ||
| – | Dihydrodipicolinate synthase [Medicago truncatula] gi|357506881|ref|XP_003623729.1| | 7 | ||
| – | PREDICTED: dihydrodipicolinate synthase 2, chloroplastic-like [Glycine max] gi|356505643|ref|XP_003521599.1| | 9 | ||
| – | PREDICTED: dihydrodipicolinate synthase 2, chloroplastic-like [Glycine max] gi|356505643|ref|XP_003521599.1| | 11 | ||
| – | PREDICTED: dihydrodipicolinate synthase 2, chloroplastic-like [Glycine max] gi|356505643|ref|XP_003521599.1| | 9 | ||
| – | PREDICTED: 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic-like [Cicer arietinum] gi|502157868|ref|XP_004510938.1| | 14 | ||
| – | PREDICTED: dihydrodipicolinate synthase 2, chloroplastic-like [Glycine max] gi|356505643|ref|XP_003521599.1| | 14 | ||
| – | 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42800|DAPA_SOYBN 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I1L6T8|I1L6T8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0463600 | 17 | ||
| – | 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42800|DAPA_SOYBN 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I1L6T8|I1L6T8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0463600 | 18 | ||
| – | 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42800|DAPA_SOYBN 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I1L6T8|I1L6T8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0463600 | 11 | ||
| – | 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT3G60880.1 dihydrodipicolinate synthase 1; Swiss-Prot: sp|Q42800|DAPA_SOYBN 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|G7L0A3|G7L0A3_MEDTR 4-hydroxy-tetrahydrodipicolinate synthase; Found in the gene: LotjaGi1g1v0463600 | 17 | ||
| – | 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42948|DAPA_TOBAC 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I1JKK4|I1JKK4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0431700 | 11 | ||
| – | 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42800|DAPA_SOYBN 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I3S7Q6|I3S7Q6_LOTJA 4-hydroxy-tetrahydrodipicolinate synthase; Found in the gene: LotjaGi3g1v0431700 | 13 | ||
| – | 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42948|DAPA_TOBAC 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|A0A151TBN5|A0A151TBN5_CAJCA 4-hydroxy-tetrahydrodipicolinate synthase; Found in the gene: LotjaGi3g1v0431800 | 14 | ||
| – | 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42948|DAPA_TOBAC 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|I1JKK4|I1JKK4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0431900 | 14 | ||
| – | 4-hydroxy-tetrahydrodipicolinate synthase; TAIR: AT2G45440.1 dihydrodipicolinate synthase; Swiss-Prot: sp|Q42800|DAPA_SOYBN 4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic; TrEMBL-Plants: tr|A0A072TNF4|A0A072TNF4_MEDTR 4-hydroxy-tetrahydrodipicolinate synthase; Found in the gene: LotjaGi4g1v0363100 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51569 | SUPERFAMILY | 1 | 5.88 |