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IPR006027 is a NusB/RsmB/TIM44.
<p>This domain is found in a number of functionally different proteins:</p> <ul> <li>NusB a prokaryotic transcription factor involved in antitermination</li> <li>TIM44, the mitochondrial inner membrane translocase subunit</li> <li>RsmB, the 16S rRNA m5C967 methyltransferase</li> </ul> <p>NusB is a prokaryotic transcription factor involved in antitermination processes, during which it interacts with the boxA portion of the mRNA nut site. Previous studies have shown that NusB exhibits an all-helical fold, and that the protein from Escherichia coli forms monomers, while Mycobacterium tuberculosis NusB is a dimer. The functional significance of NusB dimerization is unknown. An N-terminal arginine-rich sequence is the probable RNA binding site, exhibiting aromatic residues as potential stacking partners for the RNA bases. The RNA binding region is hidden in the subunit interface of dimeric NusB proteins, such as NusB from M. tuberculosis, suggesting that such dimers have to undergo a considerable conformational change or dissociate for engagement with RNA. In certain organisms, dimerization may be employed to package NusB in an inactive form until recruitment into antitermination complexes [[cite:PUB00001316], [cite:PUB00017040]].</p> <p>The antitermination proteins of E. coli are recruited in the replication cycle of Bacteriophage lambda, where they play an important role in switching from the lysogenic to the lytic cycle.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ribosomal RNA small subunit methyltransferase B-like [Cicer arietinum] gi|502099597|ref|XP_004491518.1| | 20 | ||
| – | Antitermination NusB domain-containing protein isoform 1 [Theobroma cacao] gi|508784391|gb|EOY31647.1| | 12 | ||
| – | Ribosomal RNA small subunit methyltransferase B; TAIR: AT3G13180.1 NOL1/NOP2/sun family protein / antitermination NusB domain-containing protein; Swiss-Prot: sp|P94464|RSMB_BACSU Probable ribosomal RNA small subunit methyltransferase B; TrEMBL-Plants: tr|G7KEH7|G7KEH7_MEDTR Ribosomal RNA small subunit methyltransferase B; Found in the gene: LotjaGi1g1v0015100 | 21 | ||
| – | Ribosomal RNA small subunit methyltransferase B; TAIR: AT3G13180.1 NOL1/NOP2/sun family protein / antitermination NusB domain-containing protein; Swiss-Prot: sp|P94464|RSMB_BACSU Probable ribosomal RNA small subunit methyltransferase B; TrEMBL-Plants: tr|I1JJK1|I1JJK1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0015100 | 20 | ||
| – | N utilization substance protein B like; TAIR: AT4G26370.1 antitermination NusB domain-containing protein; Swiss-Prot: sp|Q8DKS0|NUSB_THEEB N utilization substance protein B homolog; TrEMBL-Plants: tr|I3SVI4|I3SVI4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0086500 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SignalP-TM | SignalP_GRAM_NEGATIVE | 1 | 20.00 |