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IPR006236

Source: InterPro

Description

IPR006236 is a D-3-phosphoglycerate dehydrogenase.

<p>Phosphoglycerate dehydrogenases (PGDH) have at least two different structural domains: the nucleotide binding and the substrate binding. There are three types of PGDH: type 3 enzymes are composed only of these two domains, type2 enzymes contain an extra C-terminal regulatory domain (ACT domain), type 1 enzymes contain both the regulatory domain and an extra allosteric domain [[cite:PUB00069764], [cite:PUB00032650]]. This entry represents the type 1 enzyme. Interestingly, this type of PGDH is found in bacteria such as Mycobacterium, Bacillus subtilis, Corynebacterium, plants such as Arabidopsis, and higher order eukaryotes, including mammals. The PGDHs from E. coli and some lower eukaryotes, such as yeast and Neurospora, belong to the type2 PGDH and are not included in this entry [[cite:PUB00032650]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004617
Molecular function Phosphoglycerate dehydrogenase activity Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
Subterm of
GO:0006564
Biological process L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
Subterm of

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
Lj0g3v0310819.1
– PREDICTED: d-3-phosphoglycerate dehydrogenase, chloroplastic-like [Glycine max] gi|356521735|ref|XP_003529507.1|
Domains
22
Lj5g3v2113470.2
– PREDICTED: d-3-phosphoglycerate dehydrogenase, chloroplastic-like [Glycine max] gi|356536156|ref|XP_003536605.1|
Domains
29
LotjaGi3g1v0001700.2
– D-3-phosphoglycerate dehydrogenase; TAIR: AT1G17745.1 D-3-phosphoglycerate dehydrogenase; Swiss-Prot: sp|O04130|SERA2_ARATH D-3-phosphoglycerate dehydrogenase 2, chloroplastic; TrEMBL-Plants: tr|A0A1J7IRI9|A0A1J7IRI9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0001700
Domains
28
LotjaGi3g1v0343100.1
– D-3-phosphoglycerate dehydrogenase; TAIR: AT1G17745.1 D-3-phosphoglycerate dehydrogenase; Swiss-Prot: sp|O04130|SERA2_ARATH D-3-phosphoglycerate dehydrogenase 2, chloroplastic; TrEMBL-Plants: tr|I1KG47|I1KG47_SOYBN D-3-phosphoglycerate dehydrogenase; Found in the gene: LotjaGi3g1v0343100
Domains
29
LotjaGi5g1v0327800.1
– D-3-phosphoglycerate dehydrogenase; TAIR: AT4G34200.1 D-3-phosphoglycerate dehydrogenase; Swiss-Prot: sp|O49485|SERA1_ARATH D-3-phosphoglycerate dehydrogenase 1, chloroplastic; TrEMBL-Plants: tr|I1LEI9|I1LEI9_SOYBN D-3-phosphoglycerate dehydrogenase; Found in the gene: LotjaGi5g1v0327800
Domains
29

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd12173 CDD 1 20.00