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IPR006289 is a Transcription elongation factor, TFIIS.
<p>Transcription elongation factor IIS (TFIIS) is a component of RNA polymerase II preinitiation complexes, and is required for preinitiation complex assembly and stability [[cite:PUB00042911]]. The association of TFIIS with a promoter depends on functional preinitiation complex components including Mediator and the SAGA complex [[cite:PUB00042912]]. TFIIS is composed of three domains: domain 1 forms a 4-helical bundle that appears to bind certain initiation factors; domain 2 forms a 3-helical bundle and is required for Pol II binding; domain 3 forms a zinc ribbon and is essential for stimulation of RNA cleavage [[cite:PUB00042913], [cite:PUB00042914]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Nucleic acid binding | Interacting selectively and non-covalently with any nucleic acid. | ||
Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
Biological process | Transcription, DNA-templated | The cellular synthesis of RNA on a template of DNA. | ||
Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: transcription elongation factor A protein 3-like [Cicer arietinum] gi|502136750|ref|XP_004502818.1| | 29 | ||
– | PREDICTED: transcription elongation factor A protein 3-like [Cicer arietinum] gi|502136750|ref|XP_004502818.1| | 21 | ||
– | Transcription elongation factor; TAIR: AT2G38560.1 transcript elongation factor IIS; Swiss-Prot: sp|Q9ZVH8|RDO2_ARATH Transcription elongation factor TFIIS; TrEMBL-Plants: tr|I1JYC9|I1JYC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0305500 | 32 | ||
– | Transcription elongation factor; TAIR: AT2G38560.1 transcript elongation factor IIS; Swiss-Prot: sp|Q9ZVH8|RDO2_ARATH Transcription elongation factor TFIIS; TrEMBL-Plants: tr|I1JYC9|I1JYC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0305500 | 32 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 25.00 |