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IPR017923 is a Transcription factor IIS, N-terminal.
<p>Transcription factor IIS (TFIIS) is a transcription elongation factor that increases the overall transcription rate of RNA polymerase II by reactivating transcription elongation complexes that have arrested transcription. The three structural domains of TFIIS are conserved from yeast to human. The 80 or so N-terminal residues form a protein interaction domain containing a conserved motif, which has been called the LW motif because of the invariant leucine and tryptophan residues it contains. This N-terminal domain is not required for transcriptional activity, and while a similar sequence has been identified in other transcription factors, and proteins that are predominantly nuclear localized [[cite:PUB00014034], [cite:PUB00042913]], the domain is also found in proteins not directly involved in transcription. This domain is found in (amongst others):</p> <ul> <li>MED26 (also known as CRSP70 and ARC70), a subunit of the Mediator complex, which is required for the activity of the enhancer-binding protein Sp1.</li> <li>Elongin A, a subunit of a transcription elongation factor previously known as SIII. It increases the rate of transcription by suppressing transient pausing of the elongation complex.</li> <li>PPP1R10, a nuclear regulatory subunit of protein phosphatase 1 that was previously known as p99, FB19 or PNUTS.</li> <li>IWS1, which is thought to function in both transcription initiation and elongation.</li> </ul> <p>The TFIIS N-terminal domain is a compact four-helix bundle. The hydrophobic core residues of helices 2, 3, and 4 are well conserved among TFIIS domains, although helix 1 is less conserved [[cite:PUB00042913]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Lysine-specific histone demethylase-like protein [Medicago truncatula] gi|357438195|ref|XP_003589373.1| | 21 | ||
| – | PREDICTED: probable mediator of RNA polymerase II transcription subunit 26c-like [Cucumis sativus] gi|449448454|ref|XP_004141981.1| | 11 | ||
| – | PREDICTED: probable mediator of RNA polymerase II transcription subunit 26c-like [Cucumis sativus] gi|449448454|ref|XP_004141981.1| | 9 | ||
| – | BAH domain,TFIIS helical bundle-like domain isoform 1 [Theobroma cacao] gi|508773378|gb|EOY20634.1| | 15 | ||
| – | PREDICTED: transcription elongation factor A protein 3-like [Cicer arietinum] gi|502136750|ref|XP_004502818.1| | 29 | ||
| – | PREDICTED: probable mediator of RNA polymerase II transcription subunit 26c-like [Cicer arietinum] gi|502136910|ref|XP_004502892.1| | 8 | ||
| – | PREDICTED: probable mediator of RNA polymerase II transcription subunit 26c-like [Cicer arietinum] gi|502136910|ref|XP_004502892.1| | 12 | ||
| – | Lysine-specific histone demethylase-like protein [Medicago truncatula] gi|357466899|ref|XP_003603734.1| | 22 | ||
| – | PREDICTED: probable mediator of RNA polymerase II transcription subunit 26b-like isoform X1 [Cicer arietinum] gi|502108022|ref|XP_004493371.1| | 11 | ||
| – | PREDICTED: probable mediator of RNA polymerase II transcription subunit 26b-like isoform X6 [Cicer arietinum] gi|502108043|ref|XP_004493376.1| | 12 | ||
| – | PREDICTED: homeobox protein LUMINIDEPENDENS-like [Glycine max] gi|356570954|ref|XP_003553647.1| | 13 | ||
| – | PREDICTED: homeobox protein LUMINIDEPENDENS-like isoform X1 [Cicer arietinum] gi|502112497|ref|XP_004494350.1| | 13 | ||
| – | PREDICTED: serine-rich adhesin for platelets-like isoform X1 [Cicer arietinum] gi|502090725|ref|XP_004489321.1| | 16 | ||
| – | PREDICTED: protein IWS1 homolog [Glycine max] gi|356531459|ref|XP_003534295.1| | 5 | ||
| – | PREDICTED: protein IWS1 homolog [Cicer arietinum] gi|502162322|ref|XP_004512465.1| | 5 | ||
| – | PREDICTED: microtubule-associated protein futsch-like isoform X1 [Cicer arietinum] gi|502126381|ref|XP_004499286.1| | 6 | ||
| – | PREDICTED: microtubule-associated protein futsch-like isoform X1 [Cicer arietinum] gi|502126381|ref|XP_004499286.1| | 9 | ||
| – | BAH domain-containing protein, putative; TAIR: AT3G48050.1 protein SUO; Swiss-Prot: sp|F4KFC7|MD26C_ARATH Probable mediator of RNA polymerase II transcription subunit 26c; TrEMBL-Plants: tr|K7KVT9|K7KVT9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0183300 | 17 | ||
| – | Transcription elongation factor; TAIR: AT2G38560.1 transcript elongation factor IIS; Swiss-Prot: sp|Q9ZVH8|RDO2_ARATH Transcription elongation factor TFIIS; TrEMBL-Plants: tr|I1JYC9|I1JYC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0305500 | 32 | ||
| – | Transcription elongation factor; TAIR: AT2G38560.1 transcript elongation factor IIS; Swiss-Prot: sp|Q9ZVH8|RDO2_ARATH Transcription elongation factor TFIIS; TrEMBL-Plants: tr|I1JYC9|I1JYC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0305500 | 32 | ||
| – | Transcription elongation factor (TFIIS) family protein; TAIR: AT5G09850.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|F4KFC7|MD26C_ARATH Probable mediator of RNA polymerase II transcription subunit 26c; TrEMBL-Plants: tr|A0A0L9UDX4|A0A0L9UDX4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0315200 | 13 | ||
| – | Transcription elongation factor (TFIIS) family protein; TAIR: AT5G05140.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|Q9FHK9|MD26B_ARATH Probable mediator of RNA polymerase II transcription subunit 26b; TrEMBL-Plants: tr|A0A1J7HRT6|A0A1J7HRT6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0660600 | 13 | ||
| – | Transcription elongation factor (TFIIS) family protein; TAIR: AT5G05140.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|Q9FHK9|MD26B_ARATH Probable mediator of RNA polymerase II transcription subunit 26b; TrEMBL-Plants: tr|A0A1J7HRT6|A0A1J7HRT6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0660600 | 13 | ||
| – | BAH domain-containing protein; TAIR: AT3G48060.1 BAH and TFIIS domain-containing protein; Swiss-Prot: sp|F4KFC7|MD26C_ARATH Probable mediator of RNA polymerase II transcription subunit 26c; TrEMBL-Plants: tr|A0A0B2Q028|A0A0B2Q028_GLYSO Uncharacterized protein; Found in the gene: LotjaGi2g1v0249800 | 19 | ||
| – | Transcription factor IWS1, putative; TAIR: AT1G32130.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|F4ICK8|IWS1_ARATH Protein IWS1 homolog 1; TrEMBL-Plants: tr|V7CJ79|V7CJ79_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0338100 | 10 | ||
| – | Transcription factor IWS1, putative; TAIR: AT1G32130.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|F4ICK8|IWS1_ARATH Protein IWS1 homolog 1; TrEMBL-Plants: tr|V7CJ79|V7CJ79_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0338100 | 9 | ||
| – | Transcription elongation factor (TFIIS) family protein; TAIR: AT5G09850.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|F4KFC7|MD26C_ARATH Probable mediator of RNA polymerase II transcription subunit 26c; TrEMBL-Plants: tr|I1KTE5|I1KTE5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0406600 | 13 | ||
| – | Transcription elongation factor (TFIIS) family protein, putative; TAIR: AT4G24200.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|B2J717|MURC_NOSP7 UDP-N-acetylmuramate--L-alanine ligase; TrEMBL-Plants: tr|I1MC29|I1MC29_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0004800 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 3.57 |