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IPR036575 is a Transcription elongation factor S-II, central domain superfamily.
<p>Transcription factor S-II (TFIIS) induces mRNA cleavage by enhancing the intrinsic nuclease activity of RNA polymerase (Pol) II, past template-encoded pause sites. It is widely distributed being found in mammals, Drosophila, yeast and in the archaebacteria Sulfolobus acidocaldarius [[cite:PUB00004419]]. S-II proteins have a relatively conserved C-terminal region but variable N-terminal region, and some members of this family are expressed in a tissue-specific manner [[cite:PUB00006267], [cite:PUB00006554]].</p> <p>TFIIS is a modular factor that comprises an N-terminal domain I, a central domain II, and a C-terminal domain III [[cite:PUB00011910]]. The weakly conserved domain I forms a four-helix bundle and is not required for TFIIS activity. Domain II forms a three-helix bundle, and domain III adopts a zinc-ribbon fold with a thin protruding β-hairpin. Domain II and the linker between domains II and III are required for Pol II binding, whereas domain III is essential for stimulation of RNA cleavage. TFIIS extends from the polymerase surface via a pore to the internal active site, spanning a distance of 100 Angstroms. Two essential and invariant acidic residues in a TFIIS loop complement the Pol II active site and could position a metal ion and a water molecule for hydrolytic RNA cleavage. TFIIS also induces extensive structural changes in Pol II that would realign nucleic acids in the active centre.</p> <p>The superfamily represents the central domain of transcription elongation factor S-II and similar domains.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Transcription, DNA-templated | The cellular synthesis of RNA on a template of DNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Transcription elongation factor; TAIR: AT2G38560.1 transcript elongation factor IIS; Swiss-Prot: sp|Q9ZVH8|RDO2_ARATH Transcription elongation factor TFIIS; TrEMBL-Plants: tr|I1JYC9|I1JYC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0305500 | 32 | ||
| – | Transcription elongation factor; TAIR: AT2G38560.1 transcript elongation factor IIS; Swiss-Prot: sp|Q9ZVH8|RDO2_ARATH Transcription elongation factor TFIIS; TrEMBL-Plants: tr|I1JYC9|I1JYC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0305500 | 32 | ||
| – | SPOC domain/transcription elongation factor S-II, putative; TAIR: AT5G11430.1 SPOC domain / Transcription elongation factor S-II protein; Swiss-Prot: sp|Q92576|PHF3_HUMAN PHD finger protein 3; TrEMBL-Plants: tr|I1K905|I1K905_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0389600 | 12 | ||
| – | Bromo-adjacent-like (BAH) domain protein; TAIR: AT4G11560.1 bromo-adjacent homology (BAH) domain-containing protein; Swiss-Prot: sp|F4JL28|EBS_ARATH Chromatin remodeling protein EBS; TrEMBL-Plants: tr|G7KC24|G7KC24_MEDTR Bromo-adjacent-like (BAH) domain protein; Found in the gene: LotjaGi2g1v0434400 | 18 | ||
| – | Bromo-adjacent-like (BAH) domain protein; TAIR: AT4G11560.1 bromo-adjacent homology (BAH) domain-containing protein; Swiss-Prot: sp|F4JL28|EBS_ARATH Chromatin remodeling protein EBS; TrEMBL-Plants: tr|A0A0S3QXP3|A0A0S3QXP3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0425900 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |