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IPR003617 is a Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type.
<p>Transcription factor S-II (TFIIS) induces mRNA cleavage by enhancing the intrinsic nuclease activity of RNA polymerase (Pol) II, past template-encoded pause sites. It is widely distributed being found in mammals, Drosophila, yeast and in the archaebacteria Sulfolobus acidocaldarius [[cite:PUB00004419]]. S-II proteins have a relatively conserved C-terminal region but variable N-terminal region, and some members of this family are expressed in a tissue-specific manner [[cite:PUB00006267], [cite:PUB00006554]].</p> <p>TFIIS is a modular factor that comprises an N-terminal domain I, a central domain II, and a C-terminal domain III [[cite:PUB00011910]]. The weakly conserved domain I forms a four-helix bundle and is not required for TFIIS activity. Domain II forms a three-helix bundle, and domain III adopts a zinc-ribbon fold with a thin protruding β-hairpin. Domain II and the linker between domains II and III are required for Pol II binding, whereas domain III is essential for stimulation of RNA cleavage. TFIIS extends from the polymerase surface via a pore to the internal active site, spanning a distance of 100 Angstroms. Two essential and invariant acidic residues in a TFIIS loop complement the Pol II active site and could position a metal ion and a water molecule for hydrolytic RNA cleavage. TFIIS also induces extensive structural changes in Pol II that would realign nucleic acids in the active centre.</p> <p>This domain is found in the N-terminal region of transcription elongation factor S-II (TFIIS) and in several hypothetical proteins.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable mediator of RNA polymerase II transcription subunit 26c-like [Cucumis sativus] gi|449448454|ref|XP_004141981.1| | 11 | ||
| – | BAH domain,TFIIS helical bundle-like domain isoform 1 [Theobroma cacao] gi|508773378|gb|EOY20634.1| | 15 | ||
| – | PREDICTED: transcription elongation factor A protein 3-like [Cicer arietinum] gi|502136750|ref|XP_004502818.1| | 29 | ||
| – | PREDICTED: probable mediator of RNA polymerase II transcription subunit 26b-like isoform X1 [Cicer arietinum] gi|502108022|ref|XP_004493371.1| | 11 | ||
| – | PREDICTED: probable mediator of RNA polymerase II transcription subunit 26b-like isoform X6 [Cicer arietinum] gi|502108043|ref|XP_004493376.1| | 12 | ||
| – | PREDICTED: serine-rich adhesin for platelets-like isoform X1 [Cicer arietinum] gi|502090725|ref|XP_004489321.1| | 16 | ||
| – | BAH domain-containing protein, putative; TAIR: AT3G48050.1 protein SUO; Swiss-Prot: sp|F4KFC7|MD26C_ARATH Probable mediator of RNA polymerase II transcription subunit 26c; TrEMBL-Plants: tr|K7KVT9|K7KVT9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0183300 | 17 | ||
| – | Transcription elongation factor; TAIR: AT2G38560.1 transcript elongation factor IIS; Swiss-Prot: sp|Q9ZVH8|RDO2_ARATH Transcription elongation factor TFIIS; TrEMBL-Plants: tr|I1JYC9|I1JYC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0305500 | 32 | ||
| – | Transcription elongation factor; TAIR: AT2G38560.1 transcript elongation factor IIS; Swiss-Prot: sp|Q9ZVH8|RDO2_ARATH Transcription elongation factor TFIIS; TrEMBL-Plants: tr|I1JYC9|I1JYC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0305500 | 32 | ||
| – | Transcription elongation factor (TFIIS) family protein; TAIR: AT5G09850.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|F4KFC7|MD26C_ARATH Probable mediator of RNA polymerase II transcription subunit 26c; TrEMBL-Plants: tr|A0A0L9UDX4|A0A0L9UDX4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0315200 | 13 | ||
| – | Transcription elongation factor (TFIIS) family protein; TAIR: AT5G05140.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|Q9FHK9|MD26B_ARATH Probable mediator of RNA polymerase II transcription subunit 26b; TrEMBL-Plants: tr|A0A1J7HRT6|A0A1J7HRT6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0660600 | 13 | ||
| – | Transcription elongation factor (TFIIS) family protein; TAIR: AT5G05140.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|Q9FHK9|MD26B_ARATH Probable mediator of RNA polymerase II transcription subunit 26b; TrEMBL-Plants: tr|A0A1J7HRT6|A0A1J7HRT6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0660600 | 13 | ||
| – | BAH domain-containing protein; TAIR: AT3G48060.1 BAH and TFIIS domain-containing protein; Swiss-Prot: sp|F4KFC7|MD26C_ARATH Probable mediator of RNA polymerase II transcription subunit 26c; TrEMBL-Plants: tr|A0A0B2Q028|A0A0B2Q028_GLYSO Uncharacterized protein; Found in the gene: LotjaGi2g1v0249800 | 19 | ||
| – | Transcription elongation factor (TFIIS) family protein; TAIR: AT5G09850.1 Transcription elongation factor (TFIIS) family protein; Swiss-Prot: sp|F4KFC7|MD26C_ARATH Probable mediator of RNA polymerase II transcription subunit 26c; TrEMBL-Plants: tr|I1KTE5|I1KTE5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0406600 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.14 |