Description

IPR009716 is a Ferroportin-1.

<p>This entry represents the Solute carrier family 40 member 1 (SLC40A) family of proteins, also known as Ferroportin 1 (or simply ferroportin (FPN), the major iron transporter key in cellular and systemic iron levels balance. In mammals, it mediates the absorption of dietary iron by transporting ferrous iron across the basolateral surface of duodenal enterocytes and can also recycle iron from hepatocytes and macrophages. FPN is also involved in iron transfer between maternal and fetal circulation [[cite:PUB00054047], [cite:PUB00099592], [cite:PUB00099591]]. FPN synthesis is transcriptionally regulated by cellular hypoxia, iron and heme concentrations, and inflammatory signalling, while cell surface FPN is negatively regulated by hepcidin, which, under elevated serum iron levels, it blocks iron transport and induces FPN ubiquitination, internalization, and degradation [[cite:PUB00099592]]. Structural studies in Bdellovibrio bacteriovorous suggest that the putative substrate-binding site is localized deep in the N-terminal domain and demonstrated that Ca facilitates a conformational change critical to the transport cycle [[cite:PUB00099593]]. In humans, mutations in this transporter leads to nonclassical ferroportin disease (FD), a form of hereditary hemochromatosis [[cite:PUB00099591]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: