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IPR011778 is a Hydantoinase/dihydropyrimidinase.
<p>Dihydropyrimidinase (DHPase) catalyses the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines [[cite:PUB00054985]]. Primarily converts 5,6-dihydrouracil to N-carbamyl-beta-alanine (also called 3-ureidopropanoate) but also acts on dihydrothymine and hydantoin. The enzyme is a metalloenzyme [[cite:PUB00015455]].</p> <p>This entry represents the hydantoinase/dihydropyrimidinase family, which also includes D-phenylhydantoinases. This enzyme catalyses the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position, and has no activity on dihydropyrimidines [[cite:PUB00054984]].</p> <p>Dihydropyrimidinase-related proteins (collapsin response mediator proteins, CRMPs) share sequence similarity with liver DHPase. Although purified CRMP does not hydrolyse DHPase substrates, it is likely that a related activity accounts for its participation in neuronal growth cone signaling [[cite:PUB00073380]]. CRMP3 has histone H4 deacetylase activity [[cite:PUB00073343]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dihydropyrimidinase-like isoform X1 [Cicer arietinum] gi|502098432|ref|XP_004491233.1| | 23 | ||
| – | Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|G7K315|G7K315_MEDTR Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 | 20 | ||
| – | Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|G7K315|G7K315_MEDTR Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 | 20 | ||
| – | Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|A0A151T7P5|A0A151T7P5_CAJCA Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 | 13 | ||
| – | Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|A0A151T7P5|A0A151T7P5_CAJCA Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 | 13 | ||
| – | Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|G7K315|G7K315_MEDTR Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 | 13 | ||
| – | Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|A0A151T7P5|A0A151T7P5_CAJCA Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051700 | 13 | ||
| – | Dihydropyrimidinase; TAIR: AT5G12200.1 pyrimidine 2; Swiss-Prot: sp|Q9FMP3|DPYS_ARATH Dihydropyrimidinase; TrEMBL-Plants: tr|G7KCW0|G7KCW0_MEDTR Dihydropyrimidinase; Found in the gene: LotjaGi1g1v0051800 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01314 | CDD | 1 | 12.50 |