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IPR012921 is a Spen paralogue and orthologue SPOC, C-terminal.
<p>Spen (split end) proteins regulate the expression of key transcriptional effectors in diverse signalling pathways. They are large proteins characterised by N-terminal RNA-binding motifs and a highly conserved C-terminal SPOC (Spen paralog and ortholog C-terminal) domain. The function of the SPOC domain is unknown, but the SPOC domain of the SHARP Spen protein has been implicated in the interaction of SHARP with the SMRT/NcoR corepressor, where SHARP plays an essential role in the repressor complex [[cite:PUB00013949]].</p> <p>The SPOC domain is folded into a single compact domain consisting of a β-barrel with seven strands framed by six α helices. A number of deep grooves and clefts in the surface, plus two nonpolar loops, render the SPOC domain well suited to protein-protein interactions; most of the conserved residues occur on the protein surface rather than in the core. Other proteins containing a SPOC domain include Drosophila Split ends, which promotes sclerite development in the head and restricts it in the thorax, and mouse MINT (homologue of SHARP), which is involved in skeletal and neuronal development via its repression of Msx2.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: flowering time control protein FPA-like [Cicer arietinum] gi|502134068|ref|XP_004501989.1| | 15 | ||
| – | OSJNBa0033G05.18 [Oryza sativa Japonica Group] gi|38344894|emb|CAD41917.2| | 5 | ||
| – | Transcription elongation factor A protein [Medicago truncatula] gi|357466369|ref|XP_003603469.1| | 11 | ||
| – | PREDICTED: flowering time control protein FPA-like [Glycine max] gi|356538883|ref|XP_003537930.1| | 8 | ||
| – | PREDICTED: flowering time control protein FPA-like [Glycine max] gi|356538883|ref|XP_003537930.1| | 13 | ||
| – | Nucleic acid binding protein [Arabidopsis thaliana] gi|145336181|ref|NP_174096.3| | 13 | ||
| – | SPOC domain/transcription elongation factor S-II, putative; TAIR: AT5G11430.1 SPOC domain / Transcription elongation factor S-II protein; Swiss-Prot: sp|Q92576|PHF3_HUMAN PHD finger protein 3; TrEMBL-Plants: tr|I1K905|I1K905_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0389600 | 12 | ||
| – | Flowering time control protein FPA; TAIR: AT2G43410.1 RNA binding protein; Swiss-Prot: sp|Q8LPQ9|FPA_ARATH Flowering time control protein FPA; TrEMBL-Plants: tr|K7M985|K7M985_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0032200_LC | 7 | ||
| – | Flowering time control protein FPA; TAIR: AT2G43410.1 RNA binding protein; Swiss-Prot: sp|Q8LPQ9|FPA_ARATH Flowering time control protein FPA; TrEMBL-Plants: tr|K7M985|K7M985_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0032200_LC | 7 | ||
| – | RNA-binding protein; TAIR: AT2G43410.2 RNA binding protein; Swiss-Prot: sp|Q8LPQ9|FPA_ARATH Flowering time control protein FPA; TrEMBL-Plants: tr|K7LPF1|K7LPF1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0500200 | 14 | ||
| – | Nucleic acid binding protein; TAIR: AT1G27750.1 nucleic acid binding protein; Swiss-Prot: sp|Q8LPQ9|FPA_ARATH Flowering time control protein FPA; TrEMBL-Plants: tr|A0A0C3UJQ2|A0A0C3UJQ2_MEDTR SPOC domain protein; Found in the gene: LotjaGi5g1v0032800 | 12 | ||
| – | SPOC domain / transcription elongation factor S-II protein; TAIR: AT2G25640.1 SPOC domain / Transcription elongation factor S-II protein; Swiss-Prot: sp|P47169|MET5_YEAST Sulfite reductase [NADPH] subunit beta; TrEMBL-Plants: tr|A0A1J7GA37|A0A1J7GA37_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0021900_LC | 5 | ||
| – | RNA binding protein, putative; TAIR: AT4G12640.1 RNA recognition motif (RRM)-containing protein; Swiss-Prot: sp|Q8LPQ9|FPA_ARATH Flowering time control protein FPA; TrEMBL-Plants: tr|G7J619|G7J619_MEDTR RNA recognition motif (RRM) containing protein; Found in the gene: LotjaGi6g1v0192900 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.69 |