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IPR016194 is a SPOC-like, C-terminal domain superfamily.
<p>This superfamily represents the Spen Paralogue and Orthologue C-terminal (SPOC) domain and its structural homologues. This domain has a closed β-barrel fold of complex topology. Proteins that carry a SPOC-like domain include:</p> <ul> <li>Spen proteins, such as SHARP (SMRT/HDAC1-associated repressor protein), which carry a SPOC domain at the C-terminal and an RNA-binding motif in the N-terminal; Spen proteins regulate the expression of key transcriptional effectors in diverse signalling pathways, the SHARP protein being a component of transcriptional repression complexes in both nuclear receptor and Notch/RBP-Jkappa signalling pathways [[cite:PUB00013949]].</li> </ul> <ul> <li>The middle domains of Ku70 and Ku80 (which includes the C-terminal α-helical arm and the DNA encircling insertion); the Ku heterodimer, which is composed of Ku70 and Ku80 subunits, contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway [[cite:PUB00007947]].</li> </ul>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: flowering time control protein FPA-like [Cicer arietinum] gi|502134068|ref|XP_004501989.1| | 15 | ||
| – | PREDICTED: flowering time control protein FPA-like [Glycine max] gi|356538883|ref|XP_003537930.1| | 8 | ||
| – | PREDICTED: ATP-dependent DNA helicase 2 subunit KU80-like isoform X1 [Cicer arietinum] gi|502146520|ref|XP_004506489.1| | 28 | ||
| – | Nucleic acid binding protein [Arabidopsis thaliana] gi|145336181|ref|NP_174096.3| | 13 | ||
| – | PREDICTED: ATP-dependent DNA helicase 2 subunit KU70-like [Glycine max] gi|356576925|ref|XP_003556580.1| | 28 | ||
| – | Flowering time control protein FPA; TAIR: AT2G43410.1 RNA binding protein; Swiss-Prot: sp|Q8LPQ9|FPA_ARATH Flowering time control protein FPA; TrEMBL-Plants: tr|K7M985|K7M985_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0032200_LC | 7 | ||
| – | Flowering time control protein FPA; TAIR: AT2G43410.1 RNA binding protein; Swiss-Prot: sp|Q8LPQ9|FPA_ARATH Flowering time control protein FPA; TrEMBL-Plants: tr|K7M985|K7M985_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0032200_LC | 7 | ||
| – | ATP-dependent DNA helicase 2 subunit KU80; TAIR: AT1G48050.1 Ku80 family protein; Swiss-Prot: sp|Q9FQ09|KU80_ARATH ATP-dependent DNA helicase 2 subunit KU80; TrEMBL-Plants: tr|G7JDE1|G7JDE1_MEDTR ATP-dependent DNA helicase 2 subunit KU80; Found in the gene: LotjaGi3g1v0433200 | 29 | ||
| – | ATP-dependent DNA helicase 2 subunit KU80; TAIR: AT1G48050.1 Ku80 family protein; Swiss-Prot: sp|Q9FQ09|KU80_ARATH ATP-dependent DNA helicase 2 subunit KU80; TrEMBL-Plants: tr|G7JDE1|G7JDE1_MEDTR ATP-dependent DNA helicase 2 subunit KU80; Found in the gene: LotjaGi3g1v0433200 | 29 | ||
| – | ATP-dependent DNA helicase 2 subunit Ku70; TAIR: AT1G16970.1 ATP-dependent DNA helicase 2 subunit Ku70-like protein; Swiss-Prot: sp|Q9FQ08|KU70_ARATH ATP-dependent DNA helicase 2 subunit KU70; TrEMBL-Plants: tr|K7N5J8|K7N5J8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0365500 | 30 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01458 | CDD | 1 | 10.00 |