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IPR014133 is a Cryptochrome DASH.
<p>The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [[cite:PUB00076729], [cite:PUB00076730]].</p> <p>This entry represents a branch of the photolyase/cryptochrome family that is known as the cryptochrome-DASH family (Cry-DASH). The Cry-DASH family members have been shown to act as photolyases with high degree of specificity for cyclobutane pyrimidine dimers in ssDNA [[cite:PUB00076728]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA photolyase activity | Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Cryptochrome DASH [Medicago truncatula] gi|357466479|ref|XP_003603524.1| | 16 | ||
| – | PREDICTED: cryptochrome DASH, chloroplastic/mitochondrial-like [Cicer arietinum] gi|502132182|ref|XP_004501253.1| | 13 | ||
| – | Cryptochrome; TAIR: AT5G24850.1 cryptochrome 3; Swiss-Prot: sp|Q84KJ5|CRYD_ARATH Cryptochrome DASH, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7JCC1|G7JCC1_MEDTR Cryptochrome, DASH family protein; Found in the gene: LotjaGi1g1v0392600 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |