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IPR016439

Description

IPR016439 is a Sphingosine N-acyltransferase Lag1/Lac1-like.

<p>Yeast ceramide synthase component Lag1 has a paralog, Lac1. This entry includes Lac1, Lag1 and their homologues from plants and animals [[cite:PUB00073472], [cite:PUB00073471], [cite:PUB00097253]], involved in sphingolipid synthesis.</p> <p>LAG1 and LAC1 contain multiple membrane-spanning domains and are localised to the endoplasmic reticulum (ER) [[cite:PUB00073468]]. They are essential subunits of the acyl-CoA-dependent ceramide synthase that is involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine [[cite:PUB00073469], [cite:PUB00073470], [cite:PUB00009697]].</p> <p>Human Lac1/Lag1 homologue CERS2 (ceramide synthase 2) is a tumour metastasis suppressor that can inhibit breast cancer cell invasion [[cite:PUB00073765]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 15

Transcript Name Description Predicted domains Domain count
PREDICTED: ASC1-like protein-like [Glycine max] gi|356558997|ref|XP_003547788.1| 11
PREDICTED: ASC1-like protein-like [Glycine max] gi|356558997|ref|XP_003547788.1| 11
PREDICTED: LAG1 longevity assurance homolog 2-like isoform X2 [Cicer arietinum] gi|502143094|ref|XP_004505216.1| 12
PREDICTED: ASC1-like protein-like [Glycine max] gi|356558997|ref|XP_003547788.1| 11
PREDICTED: ASC1-like protein-like [Glycine max] gi|356558997|ref|XP_003547788.1| 11
PREDICTED: LAG1 longevity assurance homolog 2-like isoform X2 [Cicer arietinum] gi|502143094|ref|XP_004505216.1| 12
LAG1 longevity assurance-like protein; TAIR: AT1G13580.2 LAG1 longevity assurance-like protein; Swiss-Prot: sp|Q8W4Y5|ASCL_SOLLC ASC1-like protein; TrEMBL-Plants: tr|I1MMA9|I1MMA9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0287100 11
LAG1 longevity assurance-like protein; TAIR: AT3G19260.1 LAG1 homologue 2; Swiss-Prot: sp|Q9LJK3|LAG12_ARATH LAG1 longevity assurance homolog 2; TrEMBL-Plants: tr|A0A1J7HBE9|A0A1J7HBE9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0074100 12
LAG1 longevity assurance-like protein; TAIR: AT1G13580.2 LAG1 longevity assurance-like protein; Swiss-Prot: sp|Q8W4Y5|ASCL_SOLLC ASC1-like protein; TrEMBL-Plants: tr|I3T6V0|I3T6V0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0153300 11
LAG1 longevity assurance-like protein; TAIR: AT1G13580.2 LAG1 longevity assurance-like protein; Swiss-Prot: sp|Q8W4Y5|ASCL_SOLLC ASC1-like protein; TrEMBL-Plants: tr|I3T6V0|I3T6V0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0153300 11
LAG1 longevity assurance-like protein; TAIR: AT1G13580.2 LAG1 longevity assurance-like protein; Swiss-Prot: sp|Q8W4Y5|ASCL_SOLLC ASC1-like protein; TrEMBL-Plants: tr|I3T6V0|I3T6V0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0153300 11
LAG1 longevity assurance-like protein; TAIR: AT1G13580.2 LAG1 longevity assurance-like protein; Swiss-Prot: sp|Q8W4Y5|ASCL_SOLLC ASC1-like protein; TrEMBL-Plants: tr|I3T6V0|I3T6V0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0153300 11
LAG1 longevity assurance-like protein; TAIR: AT1G13580.2 LAG1 longevity assurance-like protein; Swiss-Prot: sp|Q6NQI8|LAG13_ARATH LAG1 longevity assurance homolog 3; TrEMBL-Plants: tr|I3T6V0|I3T6V0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0153300 11
LAG1 longevity assurance-like protein; TAIR: AT1G13580.2 LAG1 longevity assurance-like protein; Swiss-Prot: sp|Q8W4Y5|ASCL_SOLLC ASC1-like protein; TrEMBL-Plants: tr|I3T6V0|I3T6V0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0153300 11
LAG1 longevity assurance-like protein; TAIR: AT1G13580.1 LAG1 longevity assurance-like protein; Swiss-Prot: sp|Q6NQI8|LAG13_ARATH LAG1 longevity assurance homolog 3; TrEMBL-Plants: tr|I3T6V0|I3T6V0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0153300 11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 6.67